The impact of forced degradation conditions on mAb dimer formation and subsequent influence on aggregation propensity

by Michael J. Knight, Léontine Floret, Nisha Patel, John O’Hara, Elizabeth Rodriguez
Published 2022-12-01

Non-human primates in the PKPD evaluation of biologics: Needs and options to reduce, refine, and replace. A BioSafe White Paper

by Karelle Ménochet, Hongbin Yu, Bonnie Wang, Jay Tibbitts, Cheng-Pang Hsu, Amrita V. Kamath, Wolfgang F. Richter, Andreas Baumann
Published 2022-12-01

Reproducibility and flexibility of monoclonal antibody production with Nicotiana benthamiana

by Kelsi Swope, Josh Morton, Gregory P. Pogue, Leigh Burden, Nicholas Partain, Steve Hume, John Shepherd, Carrie A. Simpson, Miles B. Brennan, Thomas C. Furman, Sheila Kingrey-Gebe, Theresa Martinez, Jim McDonough, Michael H. Pauly, Kevin J. Whaley, Larry Zeitlin, Barry Bratcher, Hugh Haydon
Published 2022-12-01

In silico prediction of post-translational modifications in therapeutic antibodies

by Shabdita Vatsa
Published 2022-12-01

Beyond bispecificity: Controlled Fab arm exchange for the generation of antibodies with multiple specificities

by Desislava Yanakieva, Lukas Pekar, Andreas Evers, Markus Fleischer, Stephan Keller, Dirk Mueller-Pompalla, Lars Toleikis, Harald Kolmar, Stefan Zielonka, Simon Krah
Published 2022-12-01

Quality comparability assessment of a SARS-CoV-2-neutralizing antibody across transient, mini-pool-derived and single-clone CHO cells

by Gangling Xu, Chuanfei Yu, Wenbo Wang, Cexiong Fu, Hongchuan Liu, Yanping Zhu, Yuan Li, Chunyu Liu, Zhihao Fu, Gang Wu, Meng Li, Sha Guo, Xiaojuan Yu, Jialiang Du, Yalan Yang, Maoqin Duan, Yongfei Cui, Hui Feng, Lan Wang
Published 2022-01-01

A computational method for predicting the aggregation propensity of IgG1 and IgG4(P) mAbs in common storage buffers

by James T. Heads, Sebastian Kelm, Kerry Tyson, Alastair D. G. Lawson
Published 2022-12-01

Reduction of therapeutic antibody self-association using yeast-display selections and machine learning

by Emily K. Makowski, Hongwei Chen, Matthew Lambert, Eric M. Bennett, Nicole S. Eschmann, Yulei Zhang, Jennifer M. Zupancic, Alec A. Desai, Matthew D. Smith, Wenjia Lou, Amendra Fernando, Timothy Tully, Christopher J. Gallo, Laura Lin, Peter M. Tessier
Published 2022-12-01

Enhanced immunogenic potential of cancer immunotherapy antibodies in human IgG1 transgenic mice

by Jerome Egli, Stefan Heiler, Felix Weber, Guido Steiner, Timo Schwandt, Katharine Bray-French, Christian Klein, Sebastian Fenn, Gregor P. Lotz, Eugenia Opolka-Hoffmann, Thomas E. Kraft, Laetitia Petersen, Rebecca Moser, Jonathan DeGeer, Michel Siegel, Daniela Finke, Juliana Bessa, Antonio Iglesias
Published 2022-12-01

Computational design of a neutralizing antibody with picomolar binding affinity for all concerning SARS-CoV-2 variants

by Bo-Seong Jeong, Jeong Seok Cha, Insu Hwang, Uijin Kim, Jared Adolf-Bryfogle, Brian Coventry, Hyun-Soo Cho, Kyun-Do Kim, Byung-Ha Oh
Published 2022-12-01

Extending the capabilities of intact-mass analyses to monoclonal immunoglobulins of the E-isotype (IgE)

by Wenhua Yang, Daniil G. Ivanov, Igor A. Kaltashov
Published 2022-12-01

Challenges in antibody structure prediction

by Monica L. Fernández-Quintero, Janik Kokot, Franz Waibl, Anna-Lena M. Fischer, Patrick K. Quoika, Charlotte M. Deane, Klaus R. Liedl
Published 2023-12-01

Selection of target-binding proteins from the information of weakly enriched phage display libraries by deep sequencing and machine learning

by Tomoyuki Ito, Thuy Duong Nguyen, Yutaka Saito, Yoichi Kurumida, Hikaru Nakazawa, Sakiya Kawada, Hafumi Nishi, Koji Tsuda, Tomoshi Kameda, Mitsuo Umetsu
Published 2023-12-01

Predictive modeling of concentration-dependent viscosity behavior of monoclonal antibody solutions using artificial neural networks

by Jonathan Schmitt, Abbas Razvi, Christoph Grapentin
Published 2023-12-01

Correlated analytical and functional evaluation of higher order structure perturbations from oxidation of NISTmAb

by Tsega L. Solomon, Frank Delaglio, John P. Giddens, John P. Marino, Yihua Bruce Yu, Marc B. Taraban, Robert G. Brinson
Published 2023-12-01

Approaches to expand the conventional toolbox for discovery and selection of antibodies with drug-like physicochemical properties

by Hristo L. Svilenov, Paolo Arosio, Tim Menzen, Peter Tessier, Pietro Sormanni
Published 2023-12-01

HDX-MS study on garadacimab binding to activated FXII reveals potential binding interfaces through differential solvent exposure

by Saw Yen Ow, Eugene A. Kapp, Vesna Tomasetig, Anton Zalewski, Jason Simmonds, Con Panousis, Michael J. Wilson, Andrew D. Nash, Matthias Pelzing
Published 2023-12-01

Toward generalizable prediction of antibody thermostability using machine learning on sequence and structure features

by Ameya Harmalkar, Roshan Rao, Yuxuan Richard Xie, Jonas Honer, Wibke Deisting, Jonas Anlahr, Anja Hoenig, Julia Czwikla, Eva Sienz-Widmann, Doris Rau, Austin J. Rice, Timothy P. Riley, Danqing Li, Hannah B. Catterall, Christine E. Tinberg, Jeffrey J. Gray, Kathy Y. Wei
Published 2023-12-01

The emerging landscape of novel 4-1BB (CD137) agonistic drugs for cancer immunotherapy

by Christina Claus, Claudia Ferrara-Koller, Christian Klein
Published 2023-12-01

Bispecific antibody CAP256.J3LS targets V2-apex and CD4-binding sites with high breadth and potency

by Baoshan Zhang, Jason Gorman, Young D. Kwon, Amarendra Pegu, Cara W. Chao, Tracy Liu, Mangaiarkarasi Asokan, Michael F. Bender, Tatsiana Bylund, Leland Damron, Deepika Gollapudi, Paula Lei, Yile Li, Cuiping Liu, Mark K. Louder, Krisha McKee, Adam S. Olia, Reda Rawi, Arne Schön, Shuishu Wang, Eun Sung Yang, Yongping Yang, Kevin Carlton, Nicole A. Doria-Rose, Lawrence Shapiro, Michael S. Seaman, John R. Mascola, Peter D. Kwong
Published 2023-12-01