Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR oleh Wessel A. C. Burger, Vi Pham, Ziva Vuckovic, Alexander S. Powers, Jesse I. Mobbs, Yianni Laloudakis, Alisa Glukhova, Denise Wootten, Andrew B. Tobin, Patrick M. Sexton, Steven M. Paul, Christian C. Felder, Radostin Danev, Ron O. Dror, Arthur Christopoulos, Celine Valant, David M. Thal

"…Abstract The M4 muscarinic acetylcholine receptor (M4 mAChR) has emerged as a drug target of high therapeutic interest due to its expression in regions of the brain involved in the regulation of psychosis, cognition, and addiction. …"
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Binding epitope for recognition of human TRPM4 channel by monoclonal antibody M4M oleh Shunhui Wei, Julian Behn, Charlene Priscilla Poore, See Wee Low, Bernd Nilius, Hao Fan, Ping Liao

"…Abstract Mouse monoclonal antibody M4M was recently designed to block human TRPM4 channel. …"
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Photoelectric Photometry of Stars in the Areas of Globular Clusters M4, M22, M71 and M92 oleh Zdanavičius K.

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Early occurrence of acute myelomonocytic leukemia (M4/M5) after liver transplantation: a case report oleh Farhad Zamani, Hanie Karimi, Mohsenreza Mansoorian, Ali Basi, S. Ahmad Hosseini, Zahra Zahed, Nasim Seyedghasemipour, Roghayeh Sahraie

"…In the present report, we described a case of extramedullary acute myeloid leukemia, M4/M5 subtype, following orthotopic liver transplant. …"
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Characterization of bone marrow heterogeneity in NK-AML (M4/M5) based on single-cell RNA sequencing oleh Wenqi Wu, Zeyan Shi, Zhongyuan Tang, Huiqun Li, Xiaoke Huang, Xiaolin Liang, Jing Li, Yibin Yao, Weihua Zhao, Meiqing Wu, Jun Luo, Zhenfang Liu

"…We performed single-cell RNA sequencing to profile 39,288 cells from 6 bone marrow (BM) aspirates including 5 NK-AML (M4/M5) patients and 1 healthy donor. The single-cell transcriptome atlas and gene expression characteristics of each cell population in NK-AML (M4/M5) and healthy BM were obtained. …"
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Effect of Chemotherapy on CXCL1 and CXCL10 Levels in Acute Myeloid Leukemia Patients with M4/M5 Subtype oleh Zinat Yazdani, Iman Baluchi, Behjat Kalantary Khandany, gholamhosein hassanshahi

"…Methods: Throughout this case-control study, blood samples were collected from AML patients with M4/M5 subtype (n=25) before and after the first stage of a chemotherapy regimen (7+3). …"
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Utilization of K-nearest neighbor algorithm for classification of white blood cells in AML M4, M5, and M7 oleh Prakisya Nurcahya Pradana Taufik, Liantoni Febri, Hatta Puspanda, Aristyagama Yusfia Hafid, Setiawan Andika

"…Acute myeloid leukemia (AML) M4, M5, and M7 are subtypes of leukemia derived from myeloid cell derivatives that influences the results of the identification of AMLs, which includes myeloblast, monoblast, and megakaryoblast. …"
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Ultrasonic vocalizations induced by sex and amphetamine in M2, M4, M5 muscarinic and D2 dopamine receptor knockout mice. oleh Haoran Wang, Shuyin Liang, Jeffrey Burgdorf, Jurgen Wess, John Yeomans

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Running vacuum in quantum field theory in curved spacetime: renormalizing $$\rho _{vac}$$ ρvac without $$\sim m^4$$ ∼m4 terms oleh Cristian Moreno-Pulido, Joan Solà Peracaula

"…However, the renormalized $$\rho _{vac}(H)$$ ρvac(H) does not carry dangerous terms proportional to the quartic power of the masses ($$\sim m^4$$ ∼m4 ) of the fields, these terms being a well-known source of exceedingly large contributions. …"
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Monocytic Differentiation of Human Acute Myeloid Leukemia Cells: A Proteomic and Phosphoproteomic Comparison of FAB-M4/M5 Patients with and without Nucleophosmin 1 Mutations oleh Frode Selheim, Elise Aasebø, Håkon Reikvam, Øystein Bruserud, Maria Hernandez-Valladares

"…FAB-M4/M5 patients are heterogeneous with regard to genetic abnormalities, even though monocytic differentiation is common for patients with Nucleophosmin 1 (<i>NPM1</i>) insertions/mutations; to further study the heterogeneity of FAB-M4/M5 patients we did a proteomic and phosphoproteomic comparison of FAB-M4/M5 patients with (<i>n</i> = 13) and without (<i>n</i> = 12) <i>NPM1</i> mutations. …"
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Anti-inflammation of spirocyclopiperazinium salt compound LXM-10 targeting α7 nAChR and M4 mAChR and inhibiting JAK2/STAT3 pathway in rats. oleh Weiwei Zhang, Qi Sun, Xiaoli Gao, Yimin Jiang, Runtao Li, Jia Ye

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Computer modelling reveals new conformers of the ATP binding loop of Na+/K+-ATPase involved in the transphosphorylation process of the sodium pump oleh Gracian Tejral, Bruno Sopko, Alois Necas, Wilhelm Schoner, Evzen Amler

Subjek: "…M4M5 loop…"
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Leucémie aiguë myéloblastique et translocation (8;16) (p11;p13), premier cas marocain d'une entité clinico- biologique distincte oleh Adiba Bakkali, Mouna Lemchaheb, Nezha Had, Hind Dehbi, Said Benchekroun, Asma Quessar

Subjek: "…lam/m4-m5…"
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Development and characterization of a monoclonal antibody blocking human TRPM4 channel oleh See Wee Low, Yahui Gao, Shunhui Wei, Bo Chen, Bernd Nilius, Ping Liao

"…Two mouse monoclonal antibodies M4M and M4M1 were developed to target an extracellular epitope of human TRPM4. …"
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Addressing new challenges for a community music project in the context of higher music education: A conceptual framework

"… In response to Europe's societal challenges, such as current issues about migration, the Institute of Music Education at the University of Music and Performing Arts Graz established Meet4Music (M4M), a low-threshold community music project. M4M is open to individuals from all sociocultural and musical backgrounds and ages, and provides them with the opportunity to socialize with others and to express themselves musically. …"
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Comparison of access-hole filling materials for screw retained implant prostheses: 12-month in vivo study oleh Rémy Tanimura, Shiro Suzuki

"…The photographical analysis by VAS values showed no significant difference between CR and M4M groups (Mann-Whitney test p > 0.05, p = 0.848). …"
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Modeling genotype × environment interaction for single and multitrait genomic prediction in potato (<i>Solanum tuberosum</i> L.) oleh Jaime Cuevas, Fredrik Reslow, Jose Crossa, Rodomiro Ortiz

"…This research investigated the GP of 4 genome-based prediction models with genotype × environment interactions (GEs): (1) ST reaction norm model (M1M2M2M3M4M4M4M4,M3M2…"
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The potential of muscarinic M1 and M4 receptor activators for the treatment of cognitive impairment associated with schizophrenia oleh Samantha E. Yohn, Phillip D. Harvey, Stephen K. Brannan, William P. Horan, William P. Horan

"…This work has revealed that M1 and M4 mAChRs are highly expressed in brain regions that are implicated in cognition. …"
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Technical–tactical analysis of small combat games in male kickboxers: effects of varied number of opponents and area size oleh Ibrahim Ouergui, Slaheddine Delleli, Anissa Bouassida, Ezdine Bouhlel, Helmi Chaabene, Luca Paolo Ardigò, Emerson Franchini

"…This study investigated the effect of different within-round sparring partners number (i.e., at a time; 1 vs. 1, 1 vs. 2, and 1 vs. 4) and area sizes (2 m × 2 m, 4 m × 4 m, and 6 m × 6 m) variation on the technical–tactical aspects of small combat games in kickboxing. …"
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Striatal and nigral muscarinic type 1 and type 4 receptors modulate levodopa-induced dyskinesia and striato-nigral pathway activation in 6-hydroxydopamine hemilesioned rats oleh Alberto Brugnoli, Clarissa Anna Pisanò, Michele Morari

"…Here, we investigate whether striatal and nigral M1 and/or M4 mAChRs modulate dyskinesia and the underlying striato-nigral GABAergic pathway activation in 6-hydroxydopamine hemilesioned rats. …"
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