TRYBE®: an Fc-free antibody format with three monovalent targeting arms engineered for long in vivo half-life
ABSTRACTTrYbe® is an Fc-free therapeutic antibody format, capable of engaging up to three targets simultaneously, with long in vivo half-life conferred by albumin binding. This format is shown by small-angle X-ray scattering to be conformationally flexible with favorable ‘reach’ properties. We demon...
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Main Authors: | , , , , , , , , , , , , , , , , , |
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Format: | Journal Article |
Language: | English |
Published: |
Taylor & Francis Group
2023-12-01
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Series: | mAbs |
Subjects: | |
Online Access: | https://www.tandfonline.com/doi/10.1080/19420862.2022.2160229 |
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