Characterization and prediction of positional 4-hydroxyproline and sulfotyrosine, two post-translational modifications that can occur at substantial levels in CHO cells-expressed biotherapeutics

Characterization and prediction of positional 4-hydroxyproline and sulfotyrosine, two post-translational modifications that can occur at substantial levels in CHO cells-expressed biotherapeutics

Biotherapeutics may contain a multitude of different post-translational modifications (PTMs) that need to be assessed and possibly monitored and controlled to ensure reproducible product quality. During early development of biotherapeutics, unexpected PTMs might be prevented by in silico identificat...

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Bibliographic Details
Main Authors: Oksana Tyshchuk, Christoph Gstöttner, Dennis Funk, Simone Nicolardi, Stefan Frost, Stefan Klostermann, Tim Becker, Elena Jolkver, Felix Schumacher, Claudia Ferrara Koller, Hans Rainer Völger, Manfred Wuhrer, Patrick Bulau, Michael Mølhøj
Format: Journal Article
Language:English
Published: Taylor & Francis Group 2019-10-01
Series:mAbs
Subjects:
Biotherapeutics
fab purification
MALDI-ISD FT-ICR
hydroxyproline
mass spectrometry
PTM
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2019.1635865
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https://www.tandfonline.com/doi/10.1080/19420862.2019.1635865

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