Bispecific VH/Fab antibodies targeting neutralizing and non-neutralizing Spike epitopes demonstrate enhanced potency against SARS-CoV-2

Bispecific VH/Fab antibodies targeting neutralizing and non-neutralizing Spike epitopes demonstrate enhanced potency against SARS-CoV-2

Numerous neutralizing antibodies that target SARS-CoV-2 have been reported, and most directly block binding of the viral Spike receptor-binding domain (RBD) to angiotensin-converting enzyme II (ACE2). Here, we deliberately exploit non-neutralizing RBD antibodies, showing they can dramatically assist...

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Bibliographic Details
Main Authors: Shion A. Lim, Josef A. Gramespacher, Katarina Pance, Nicholas J. Rettko, Paige Solomon, Jing Jin, Irene Lui, Susanna K. Elledge, Jia Liu, Colton J. Bracken, Graham Simmons, Xin X. Zhou, Kevin K. Leung, James A. Wells
Format: Journal Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:mAbs
Subjects:
Bispecific
neutralizing antibody
knob-in-hole
COVID-19
SARS-CoV-2
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2021.1893426
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https://www.tandfonline.com/doi/10.1080/19420862.2021.1893426

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