Failure of thymic deletion and instability of autoreactive Tregs drive autoimmunity in immune-privileged liver

Failure of thymic deletion and instability of autoreactive Tregs drive autoimmunity in immune-privileged liver

The liver is an immune-privileged organ that can deactivate autoreactive T cells. Yet in autoimmune hepatitis (AIH), autoreactive T cells can defy hepatic control and attack the liver. To elucidate how tolerance to self-antigens is lost during AIH pathogenesis, we generated a spontaneous mouse model...

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Bibliographic Details
Main Authors: Max Preti, Lena Schlott, David Lübbering, Daria Krzikalla, Anna-Lena Müller, Fenja A. Schuran, Tobias Poch, Miriam Schakat, Sören Weidemann, Ansgar W. Lohse, Christina Weiler-Normann, Marcial Sebode, Dorothee Schwinge, Christoph Schramm, Antonella Carambia, Johannes Herkel
Format: Journal Article
Language:English
Published: American Society for Clinical investigation 2021-03-01
Series:JCI Insight
Subjects:
Autoimmunity
Hepatology
Online Access:https://doi.org/10.1172/jci.insight.141462
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https://doi.org/10.1172/jci.insight.141462

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