Functional GLP-1R antibodies identified from a synthetic GPCR-focused library demonstrate potent blood glucose control

Functional GLP-1R antibodies identified from a synthetic GPCR-focused library demonstrate potent blood glucose control

G protein-coupled receptors (GPCRs) are a group of seven-transmembrane receptor proteins that have proven to be successful drug targets. Antibodies are becoming an increasingly promising modality to target these receptors due to their unique properties, such as exquisite specificity, long half-life,...

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Bibliographic Details
Main Authors: Qiang Liu, Pankaj Garg, Burcu Hasdemir, Linya Wang, Emily Tuscano, Emily Sever, Erica Keane, Ana G Lujan Hernandez, Tom Z. Yuan, Eric Kwan, Joyce Lai, Greg Szot, Sreenivasan Paruthiyil, Fumiko Axelrod, Aaron K. Sato
Format: Journal Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:mAbs
Subjects:
GPCR
glp-1 peptide
phage display library
panning
antagonist
agonist
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2021.1893425
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https://www.tandfonline.com/doi/10.1080/19420862.2021.1893425

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