Discovery and characterization of a monoclonal antibody targeting a conformational epitope of IL-6/IL-6Rα to inhibit IL-6/ IL-6Rα/gp130 hexameric signaling complex formation

Discovery and characterization of a monoclonal antibody targeting a conformational epitope of IL-6/IL-6Rα to inhibit IL-6/ IL-6Rα/gp130 hexameric signaling complex formation

The functional interleukin 6 (IL-6) signaling complex is a hexameric structure composed of IL-6, IL-6Rα, and the signaling receptor gp130. There are three different modes of IL-6 signaling, classic signaling, trans-signaling, and trans-presentation, which are not functionally redundant and mediate p...

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Bibliographic Details
Main Authors: Chun-Chi Chou, Kuo-Tai Hua, Min-Wei Chen, Chin-Jui Wu, Chun-Hua Hsu, Jann-Tay Wang, Michael Hsiao, Lin-Hung Wei
Format: Journal Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:mAbs
Subjects:
il-6/il-6rα complex
gp130
site 3
neutralization
antibody
Online Access:http://dx.doi.org/10.1080/19420862.2022.2029675
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http://dx.doi.org/10.1080/19420862.2022.2029675

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