Antibody Fc engineering for enhanced neonatal Fc receptor binding and prolonged circulation half-life

Antibody Fc engineering for enhanced neonatal Fc receptor binding and prolonged circulation half-life

The neonatal Fc receptor (FcRn) promotes antibody recycling through rescue from normal lysosomal degradation. The binding interaction is pH-dependent with high affinity at low pH, but not under physiological pH conditions. Here, we combined rational design and saturation mutagenesis to generate nove...

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Bibliographic Details
Main Authors: Brian C. Mackness, Julie A. Jaworski, Ekaterina Boudanova, Anna Park, Delphine Valente, Christine Mauriac, Olivier Pasquier, Thorsten Schmidt, Mostafa Kabiri, Abdullah Kandira, Katarina Radošević, Huawei Qiu
Format: Journal Article
Language:English
Published: Taylor & Francis Group 2019-10-01
Series:mAbs
Subjects:
IgG antibodies
neonatal Fc receptor
mutagenesis
serum half-life
pH dependence
FcRn
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2019.1633883
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https://www.tandfonline.com/doi/10.1080/19420862.2019.1633883

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