Harnessing the potential of machine learning for advancing “Quality by Design” in biomanufacturing

by Ian Walsh, Matthew Myint, Terry Nguyen-Khuong, Ying Swan Ho, Say Kong Ng, Meiyappan Lakshmanan
Published 2022-12-01

Systematic analysis of the varied designs of 819 therapeutic antibodies and Fc fusion proteins assigned international nonproprietary names

by Ian Wilkinson, Geoff Hale
Published 2022-12-01

Ab-Ligity: identifying sequence-dissimilar antibodies that bind to the same epitope

by Wing Ki Wong, Sarah A. Robinson, Alexander Bujotzek, Guy Georges, Alan P. Lewis, Jiye Shi, James Snowden, Bruck Taddese, Charlotte M. Deane
Published 2021-01-01

Antibody mix-and-read assays based on fluorescence intensity probes

by Ujwal Patil, Atul Goyal, Binh Vu, Yanyun Liu, Vijay Maranholkar, Katerina Kourentzi, James M. Briggs, Richard C. Willson
Published 2021-01-01

Isolation and characterization of monoclonal antibodies against human carbonic anhydrase-IX

by Anne E.G. Lenferink, Paul C. McDonald, Christiane Cantin, Suzanne Grothé, Mylene Gosselin, Jason Baardsnes, Myriam Banville, Paul Lachance, Alma Robert, Yuneivy Cepero-Donates, Stevo Radinovic, Patrick Salois, Marie Parat, Hafida Oamari, Annie Dulude, Mehul Patel, Martin Lafrance, Andrea Acel, Nathalie Bousquet-Gagnon, Denis L’Abbé, Alex Pelletier, Félix Malenfant, Maria Jaramillo, Maureen O’Connor-Mccourt, Cunle Wu, Yves Durocher, Mélanie Duchesne, Christine Gadoury, Anne Marcil, Yves Fortin, Beatrice Paul-Roc, Maurizio Acchione, Shawn C. Chafe, Oksana Nemirovsky, Joseph Lau, Francois Bénard, Shoukat Dedhar
Published 2021-01-01

Impact of IgG subclass on molecular properties of monoclonal antibodies

by Yu Tang, Paul Cain, Victor Anguiano, James J. Shih, Qing Chai, Yiqing Feng
Published 2021-01-01

Differences in human IgG1 and IgG4 S228P monoclonal antibodies viscosity and self-interactions: Experimental assessment and computational predictions of domain interactions

by Pin-Kuang Lai, Gaurav Ghag, Yao Yu, Veronica Juan, Laurence Fayadat-Dilman, Bernhardt L. Trout
Published 2021-01-01

An integrated approach for characterizing immunogenic responses toward a bispecific antibody

by Sivan Cohen, Shan Chung, Christoph Spiess, Victor Lundin, Eric Stefanich, Steven T. Laing, Vanessa Clark, Jochen Brumm, Ying Zhou, Catherine Huang, Joyce Guerrero, Srividya Myneni, Rajbharan Yadav, Ketevan Siradze, Kun Peng
Published 2021-01-01

Quantification of natural abundance NMR data differentiates the solution behavior of monoclonal antibodies and their fragments

by David Ban, Cory T. Rice, Mark A. McCoy
Published 2021-01-01

Bifunctional molecules targeting SARS-CoV-2 spike and the polymeric Ig receptor display neutralization activity and mucosal enrichment

by Ian White, Ninkka Tamot, Rajitha Doddareddy, Jason Ho, Qun Jiao, Paul B. Harvilla, Tong-Yuan Yang, Brian Geist, M. Jack Borrok, Matthew D. Truppo, Rajkumar Ganesan, Partha Chowdhury, Adam Zwolak
Published 2021-01-01

A human antibody of potent efficacy against SARS-CoV-2 in rhesus macaques showed strong blocking activity to B.1.351

by Chunyin Gu, Xiaodan Cao, Zongda Wang, Xue Hu, Yanfeng Yao, Yiwu Zhou, Peipei Liu, Xiaowu Liu, Ge Gao, Xiao Hu, Yecheng Zhang, Zhen Chen, Li Gao, Yun Peng, Fangfang Jia, Chao Shan, Li Yu, Kunpeng Liu, Nan Li, Weiwei Guo, Guoping Jiang, Juan Min, Jianjian Zhang, Lu Yang, Meng Shi, Tianquan Hou, Yanan Li, Weichen Liang, Guoqiao Lu, Congyi Yang, Yuting Wang, Kaiwen Xia, Zheng Xiao, Jianhua Xue, Xueyi Huang, Xin Chen, Haixia Ma, Donglin Song, Zhongzong Pan, Xueping Wang, Haibing Guo, Hong Liang, Zhiming Yuan, Wuxiang Guan, Su-Jun Deng
Published 2021-01-01

Characterizing and understanding the formation of cysteine conjugates and other by-products in a random, lysine-linked antibody drug conjugate

by Difei Qiu, Yande Huang, Naresh Chennamsetty, Scott A. Miller, Michael Hay
Published 2021-01-01

Ensembles in solution as a new paradigm for antibody structure prediction and design

by Monica L. Fernández-Quintero, Guy Georges, Janos M. Varga, Klaus R. Liedl
Published 2021-01-01

An efficient system for bioconjugation based on a widely applicable engineered O-glycosylation tag <subtitle>Short title: Controlled bioconjugation via O-glycan engineering</subtit...

by Thomas V. Murray, Kasia Kozakowska-McDonnell, Adam Tibbles, Annabel Taylor, Daniel Higazi, Emmanuel Rossy, Alessandra Rossi, Sivaneswary Genapathy, Giulia Tamburrino, Nicola Rath, Natalie Tigue, Vivian Lindo, Tristan Vaughan, Monika A. Papworth
Published 2021-01-01

Current strategies for detecting functional convergence across B-cell receptor repertoires

by Matthew I. J. Raybould, Anthony R. Rees, Charlotte M. Deane
Published 2021-01-01

Highly sensitive detection of antibody nonspecific interactions using flow cytometry

by Emily K. Makowski, Lina Wu, Alec A. Desai, Peter M. Tessier
Published 2021-01-01

Agonistic nanobodies and antibodies to human VISTA

by Yu-Heng Vivian Ma, Amanda Sparkes, Ema Romão, Shrayasee Saha, Jean Gariépy
Published 2021-01-01

Identification of critical chemical modifications and paratope mapping by size exclusion chromatography of stressed antibody-target complexes

by Pavel V. Bondarenko, Andrew C. Nichols, Gang Xiao, Rachel Liuqing Shi, Pik Kay Chan, Thomas M Dillon, Fernando Garces, David J. Semin, Margaret S. Ricci
Published 2021-01-01

Rational selection of building blocks for the assembly of bispecific antibodies

by Danyang Gong, Timothy P. Riley, Krzysztof P. Bzymek, Ana R. Correia, Danqing Li, Christopher Spahr, John H. Robinson, Ryan B. Case, Zhulun Wang, Fernando Garces
Published 2021-01-01

Challenges of non-clinical safety testing for biologics: A Report of the 9th BioSafe European Annual General Membership Meeting

by Thomas Kissner, Guenter Blaich, Andreas Baumann, Sven Kronenberg, Adam Hey, Andrea Kiessling, Petra M. Schmitt, Wouter Driessen, Chantal Carrez, Daniel Kramer, Jennifer Fretland, Wolfgang F. Richter, Tobias Paehler, Ulrike Hopfer, Benno Rattel
Published 2021-01-01