Impacts of Major Changes in China’s COVID-19 Prevention and Control Policies on Emergency Department Visits: A Quasi-Experiment oleh Zhang Y, Xiao C, Huang G, Shen M

"…Yang Zhang,1,* Chenggen Xiao,2,* Guoqing Huang,2 Minxue Shen1,3 1Department of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha City, Hunan Province, People’s Republic of China; 2Department of Emergency, Xiangya Hospital, Central South University, Changsha City, Hunan Province, People’s Republic of China; 3Furong Laboratory, Central South University, Changsha City, Hunan Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Guoqing Huang; Minxue Shen, Email hgq97@126.com; shenmx1988@csu.edu.cnObjective: This study aims to evaluate the impact of COVID-19 prevention and control policies on the frequency of emergency department (ED) visits in a large tertiary hospital in central China, from January 2018 to September 2023.Methods: We conducted a multi-stage interrupted time series analysis to investigate the impact of various epidemic control policies on weekly ED visits at a tertiary hospital in Hunan Province, China. …"
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AVE 0991 Suppresses Astrocyte-Mediated Neuroinflammation of Alzheimer’s Disease by Enhancing Autophagy oleh Deng Y, Wang SY, Wang QG, Xu ZH, Peng Q, Chen SY, Zhu L, Zhang YD, Duan R

"…Yang Deng,1,* Si-Yu Wang,2,* Qing-Guang Wang,3,* Zhao-Han Xu,2 Qiang Peng,2 Shuai-Yu Chen,2 Lin Zhu,2 Ying-Dong Zhang,1,2 Rui Duan1,2 1Department of Neurology, Nanjing First Hospital, China Pharmaceutical University, Nanjing, People’s Republic of China; 2Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, People’s Republic of China; 3Department of Neurology, Jiangyin Hospital Affiliated to Nantong University, Jiangyin, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ying-Dong Zhang; Rui Duan, Department of Neurology, Nanjing First Hospital, China Pharmaceutical University, No.68, Changle Road, Nanjing, Jiangsu, People’s Republic of China, Email zhangyingdong@njmu.edu.cn; duanruicpu@163.comPurpose: Our previous study has shown that AVE 0991, a nonpeptide analogue of Ang-(1-7), ameliorates cognitive decline and inhibits NLRP3 inflammasome of astrocytes in Alzheimer’s disease model mice. …"
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Targeted delivery of anti-miR-155 by functionalized mesoporous silica nanoparticles for colorectal cancer therapy oleh Li Y, Duo Y, Bi J, Zeng X, Mei L, Bao S, He L, Shan A, Zhang Y, Yu X

"…Yang Li,1,2,* Yanhong Duo,1,3,* Jiangang Bi,1 Xiaowei Zeng,4 Lin Mei,4 Shiyun Bao,1 Lisheng He,5 Aijun Shan,2 Yue Zhang,1 Xiaofang Yu1 1Department of Hepatobiliary and Pancreas Surgery, Second Clinical Medical College of Jinan University, Shenzhen People’s Hospital, Shenzhen 518020, China; 2Department of Emergency, Second Clinical Medical College of Jinan University, Shenzhen People’s Hospital, Shenzhen 518020, China; 3Key Laboratory of Plant Cell Activities and Stress Adaptation, Ministry of Education, School of Life Sciences, Lanzhou University, Lanzhou 730000, China; 4Division of Life and Health Sciences, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518020, China; 5Department of Pathology, Second Clinical Medical College of Jinan University, Shenzhen People’s Hospital, Shenzhen 518020, China *These authors contributed equally to this work Introduction: MicroRNA-155 (miR-155) is an oncogenic microRNA, which is upregulated in many human cancers including colorectal cancer (CRC). …"
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Caudal-Type Homeobox Transcription Factor 2 is a Favorable Prognostic Indicator in Stage II and III Gastric Cancer Following Curative Surgery oleh Xu Y, Wu Y, Liu J, Xiao L, Zhang Y

"…Yang Xu,1,* Yue Wu,1,* Jianhong Liu,2 Lili Xiao,1 Ying Zhang1 1Department of Gastroenterology, Daqing Oilfield General Hospital, Daqing, Heilongjiang, 163000, People’s Republic of China; 2Department of Breast and Thyroid Surgery, Daqing Oilfield General Hospital, Daqing, Heilongjiang, 163000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ying Zhang, Email zhangying750114@163.comBackground: The study explored the prognostic value of caudal-type homeobox transcription factor 2 (CDX2) in stage II and III gastric cancer.Methods: This study evaluated the expression level of CDX2 in gastric cancer in a hospital cohort (n=197) using immunohistochemistry. …"
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The Effect of Subsequent Pregnancy on Prognosis in Young Breast Cancer Patients (≤35 Years Old) According to Hormone Receptor Status oleh Li Y, Zhang Y, Wang S, Lu S, Song Y, Liu H

"…Yang Li,1 Yuhan Zhang,1 Shuaibing Wang,2 Su Lu,1 Yixuan Song,1 Hong Liu1 1The Second Surgical Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin, 300060, People’s Republic of China; 2Oncology Department, China National Petroleum Corporation Central Hospital, Langfang, Hebei Province, 065000, People’s Republic of ChinaCorrespondence: Hong LiuThe Second Surgical Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, Huanhu West Road, Hexi District, Tianjin, 300060, People’s Republic of ChinaTel +86-18622221169Email liuhongzhang0101@163.comPurpose: We aimed to examine the effect of pregnancy on prognosis in young breast cancer (YBC) patients with hormone receptor (HR) positive after surgery and the safety of interrupting endocrine therapy (ET).Methods: A retrospective cohort study was performed in patients who became pregnant after BC surgery under the age of 35 and were matched (1:4) to nonpregnant patients from 2006 to 2014. …"
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Comparing common reasons for inpatient and outpatient visits between commercially-insured duloxetine or pregabalin initiators with fibromyalgia oleh Zhao Y, Sun P, Bernauer M

"…Yang Zhao,1 Peter Sun,2 Mark Bernauer31Eli Lilly and Company, 2Kailo Research Group, 3OptumInsight, Indianapolis, IN, USABackground: The purpose of this study was to examine the main reasons for inpatient or outpatient visits after initiating duloxetine or pregabalin.Methods: Commercially insured patients with fibromyalgia and aged 18–64 years who initiated duloxetine or pregabalin in 2006 with 12-month continuous enrollment before and after initiation were identified. …"
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Clinical Efficacy and Diagnostic Value of Metagenomic Next-Generation Sequencing for Pathogen Detection in Patients with Suspected Infectious Diseases: A Retrospective Study from a... oleh Xiao YH, Liu MF, Wu H, Xu DR, Zhao R

"…Yang-Hua Xiao,1,2 Mei-Fang Liu,1 Hongwen Wu,1,3 De-Rong Xu,1 Rui Zhao1 1Department of Clinical Laboratory, Medical Center for Burn and Plastic Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, People’s Republic of China; 2School of Public Health, Nanchang University, Nanchang, People’s Republic of China; 3Department of Medical Instruments, The First Affiliated Hospital of Nanchang University, Nanchang, People’s Republic of ChinaCorrespondence: De-Rong Xu; Rui Zhao, Email xudr@ncu.edu.cn; zhaoruisc@163.comPurpose: Metagenomic next-generation sequencing (mNGS) is a powerful yet unbiased method to identify pathogens in suspected infections. …"
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Identification of Hub Diagnostic Biomarkers and Candidate Therapeutic Drugs in Heart Failure oleh Guo Y, Ning B, Zhang Q, Ma J, Zhao L, Lu Q, Zhang D

"…Yang Guo,1– 4 Bobin Ning,5 Qunhui Zhang,1– 4 Jing Ma,4 Linlin Zhao,1– 4 QiQin Lu,1– 4 Dejun Zhang1,4 1Research Center for High Altitude Medicine, Medical College of Qinghai University, Xining, 810001, People’s Republic of China; 2Key Laboratory of Application and Foundation for High Altitude Medicine Research in Qinghai Province, Medical College of Qinghai University, Xining, 810001, People’s Republic of China; 3Qinghai-Utah Joint Research Key Lab for High Altitude Medicine, Medical College of Qinghai University, Xining, 810001, People’s Republic of China; 4Department of Eco-Environmental Engineering, Qinghai University, Xining, 810016, People’s Republic of China; 5Department of Medicine, The General Hospital of the People’s Liberation Army, Beijing, 100038, People’s Republic of ChinaCorrespondence: Dejun ZhangDepartment of Eco-Environmental Engineering, Qinghai University, Qinghai, 810016, People’s Republic of ChinaEmail djzhangqhu@163.comPurpose: The objective of this study was to identify the potential regulatory mechanisms, diagnostic biomarkers, and therapeutic drugs for heart failure (HF).Methods: Differentially expressed genes (DEGs) between HF and non-failing donors were screened from the GSE57345, GSE5406, and GSE3586 datasets. …"
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Impact of Preoperative Sleep Disturbances on Postoperative Delirium in Patients with Intracranial Tumors: A Prospective, Observational, Cohort Study oleh Liu Y, Zhang X, Jiang M, Zhang Y, Wang C, Sun Y, Shi Z, Wang B

"…Yang Liu,1 Xiaoyu Zhang,1 Mengyang Jiang,1 Yiqiang Zhang,1 Chenhui Wang,1 Yongxing Sun,1 Zhonghua Shi,2 Baoguo Wang1 1Department of Anesthesiology, Sanbo Brain Hospital, Capital Medical University, Beijing, 100093, People’s Republic of China; 2Department of Intensive Care Medicine, Sanbo Brain Hospital, Capital Medical University, Beijing, 100093, People’s Republic of ChinaCorrespondence: Baoguo Wang, Department of Anesthesiology, Sanbo Brain Hospital, Capital Medical University, No. 50 Xiangshan Yi-Ke-Song Road, Haidian District, Beijing, 100093, People’s Republic of China, Tel +86 13370185075, Email wangbg@ccmu.edu.cnBackground: Postoperative delirium (POD) is prevalent in craniotomy patients and is associated with high mortality. …"
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Construction of a Ferroptosis-Related Gene Signature for Head and Neck Squamous Cell Carcinoma Prognosis Prediction oleh Li Q, Jin Y, Shen Z, Liu H, Shen Y, Wu Z

"…Qun Li,1 Yangli Jin,2 Zhisen Shen,1 Huigao Liu,3 Yi Shen,1 Zhenhua Wu1 1Department of Otorhinolaryngology Head and Neck Surgery, Ningbo Medical Center Lihuili Hospital, Ningbo, Zhejiang, People’s Republic of China; 2Department of Doppler Ultrasonic, Ningbo Yinzhou No.2 Hospital, Ningbo, Zhejiang, People’s Republic of China; 3Department of Otorhinolaryngology Head and Neck Surgery, Ningbo Zhenhai Longsai Hospital, Ningbo, Zhejiang, People’s Republic of ChinaCorrespondence: Zhenhua WuDepartment of Otorhinolaryngology Head and Neck Surgery, Ningbo Medical Center Lihuili Hospital, No. 57 Xingning Road, Yinzhou District, Ningbo, 315040, People’s Republic of ChinaTel +86-574-87018634Fax +86-574-87018634Email wuzhenhua1975@126.comBackground: Head and neck squamous cell carcinoma (HNSCC) is one of the most common malignant cancers, and few studies have demonstrated the value of ferroptosis-related genes in prognosis.Methods: The original counts of RNA sequencing data and clinicopathological data were obtained from TCGA and GSE65858 datasets. …"
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Temporal Trends in the Disease Burden of Colorectal Cancer with Its Risk Factors at the Global and National Level from 1990 to 2019, and Projections Until 2044 oleh Liu Y, Zhang C, Wang Q, Wu K, Sun Z, Tang Z, Zhang B

"…Yang Liu,1 Chao Zhang,2 Qianwen Wang,1 Kangze Wu,3 Zhouyi Sun,1 Zhe Tang,1 Bo Zhang3 1The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, Zhejiang, 322000, People’s Republic of China; 2Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, People’s Republic of China; 3The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310000, People’s Republic of ChinaCorrespondence: Bo Zhang, The Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, Zhejiang, 310000, People’s Republic of China, Tel/Fax +86-0571-87783563, Email jjs10@zju.edu.cnBackground: This study aimed to evaluate the global colorectal cancer(CRC) trend and the relevant risk factors from 1990 to 2019 and for better policymaking and resource allocation.Methods: Data on CRC, including incidence, mortality and disability adjusted life year (DALY) rates, were extracted from the 2019 Global Burden of Disease (GBD) study. …"
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Analysis of Human microRNA Expression Profiling During Diquat-Induced Renal Proximal Tubular Epithelial Cell Injury oleh Chen Y, Li HY, Liu JS, Jiang DL, Zheng HN, Dong XS

"…Yang Chen,1 Hui-Yi Li,1 Jian-Shu Liu,1 Dao-long Jiang,1 Hao-nan Zheng,2 Xue-Song Dong1 1Department of Emergency, The First Hospital of China Medical University, Shenyang, 110001, People’s Republic of China; 2No.105 Phase, The First Clinical College of China Medical University, Shenyang, 110001, People’s Republic of ChinaCorrespondence: Xue-Song Dong, Department of Emergency, The First Hospital of China Medical University, No. 155 of Nanjing North Street, Heping District, Shenyang, 110001, People’s Republic of China, Tel +86 024-26111099 ; +86 024-83282011, Email dongxunsongdxs0@126.comBackground: We established a diquat-induced human kidney-2 cells (HK-2 cells) apoptosis model in this study to identify differentially expressed microRNAs (miRNAs) and signaling pathways involved in diquat poisoning via gene sequencing and bioinformatics analysis and explored the related therapeutic benefits.Methods: The effects of diquat on the viability and apoptosis of HK-2 cells were explored using the CCK-8 and Annexin V-FITC/PI double staining methods. …"
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Evaluation of Antiemetic Therapy for Hepatic Arterial Infusion Chemotherapy with Oxaliplatin, Fluorouracil, and Leucovorin oleh Zhao Y, He M, Liang R, Li Q, Shi M

"…Yang Zhao, MinKe He, RunBin Liang, QiJiong Li, Ming Shi Department of Hepatobiliary Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People’s Republic of ChinaCorrespondence: Ming ShiDepartment of Hepatobiliary Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, People’s Republic of ChinaTel/Fax +86-020-87343938Email shiming@sysu.edu.cnPurpose: Our aim was to compare the antiemetic efficacy of the triple combination of aprepitant, dolasetron and dexamethasone with the combination of dolasetron and dexamethasone for chemotherapy-induced nausea and vomiting (CINV) in hepatocellular carcinoma (HCC) patients receiving hepatic arterial infusion chemotherapy (HAIC) with oxaliplatin, fluorouracil and leucovorin (FOLFOX).Patients and Methods: This was a retrospective study. …"
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Costunolide Inhibits Chronic Kidney Disease Development by Attenuating IKKβ/NF-κB Pathway oleh Zhao Y, Wang YH, Tu WC, Wang DW, Lu MJ, Shao Y

"…Yang Zhao,1,* Yi-Han Wang,2,* Wei-Chao Tu,1 Da-Wei Wang,1 Mu-Jun Lu,3,4 Yuan Shao1 1Department of Urology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, Shanghai, 201800, People’s Republic of China; 2Department of Urology, Sixth People’s Hospital South Campus Affiliated to Shanghai Jiao Tong University, Shanghai, People’s Republic of China; 3Department of Urology and Andrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People’s Republic of China; 4Shanghai Institute of Andrology, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Mu-Jun Lu; Yuan Shao, Email lumujun@163.com; shaoyuan10772@163.comBackground: Chronic kidney disease (CKD) is a significant worldwide health concern that leads to high mortality rates. …"
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Cycloserine for treatment of multidrug-resistant tuberculosis: a retrospective cohort study in China oleh Li Y, Wang F, Wu L, Zhu M, He G, Chen X, Sun F, Liu Q, Wang X, Zhang W

"…Yang Li,1,* Fei Wang,2,* Limin Wu,3 Min Zhu,4 Guiqing He,5 Xinchang Chen,1 Feng Sun,1 Qihui Liu,1 Xiaomeng Wang,2 Wenhong Zhang1 1Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai 200032, China; 2Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang 310051, China; 3Hangzhou Center for Disease Control and Prevention, Hangzhou, Zhejiang 310021, China; 4Tuberculosis Treatment Center, Hangzhou Red Cross Hospital, Hangzhou 310003, China; 5Department of Infectious Diseases, Wenzhou Center Hospital, Wenzhou 325000, China *These authors contributed equally to this work Purpose: Cycloserine has been used in multidrug-resistant tuberculosis (MDR-TB) treatment since the 1950s. …"
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Facile Synthesis and Properties of Highly Porous Quartz Fiber-Reinforced Phenolic Resin Composites with High Strength oleh Xin Tao, Yange Wan, Ruoyu Zhang, Yuqing Zhang, Yu Wang, Xiaolei Yu, Mingchao Wang

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Pharmacological Evaluation of Total Alkaloids from Nux Vomica: Effect of Reducing Strychnine Contents oleh Jun Chen, Yange Qu, Dongyue Wang, Pei Peng, Hao Cai, Ying Gao, Zhipeng Chen, Baochang Cai

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Construction, validation and, visualization of a web-based nomogram to identify the best candidates for primary tumor resection in advanced cutaneous melanoma patients oleh Zhehong Li, Zhehong Li, Junqiang Wei, Honghong Zheng, Yafang Zhang, Yange Zhang, Haiying Cao, Yu Jin

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An online statistical analysis of the hotel management and operation performance model oleh Fang Hui, Ou Yangli, Fu Tianyi

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Optimization of a thermoelectric cooler-based system for atmospheric water production in terms of temperature of condensing surface oleh Jie Wang, Yange Suo, Hanqing Lou, Yanghui Ye, Zhiguo Zhang

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