Pediatric-type high-grade neuroepithelial tumors with CIC gene fusion share a common DNA methylation signature oleh Philipp Sievers, Martin Sill, Daniel Schrimpf, Zied Abdullaev, Andrew M. Donson, Jessica A. Lake, Dennis Friedel, David Scheie, Olli Tynninen, Tuomas Rauramaa, Kaisa L. Vepsäläinen, David Samuel, Rebecca Chapman, Richard G. Grundy, Kristian W. Pajtler, Arnault Tauziède-Espariat, Alice Métais, Pascale Varlet, Matija Snuderl, Thomas S. Jacques, Kenneth Aldape, David E. Reuss, Andrey Korshunov, Wolfgang Wick, Stefan M. Pfister, Andreas von Deimling, Felix Sahm, David T. W. Jones

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Undesirable events during electronic cigarette use prior to the implementation of Article 20 of the European Union Tobacco Products Directive: Findings from the EUREST-PLUS ITC Eur... oleh Christina N. Kyriakos, Filippos T. Filippidis, Sara Hitchman, Charis Girvalaki, Chara Tzavara, Tibor Demjén, Esteve Fernández, Ute Mons, Antigona Trofor, Yannis Tountas, Mateusz Zatoński, Witold A. Zatoński, Geoffrey T. Fong, Constantine I. Vardavas, on behalf of the EUREST-PLUS consortium

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Free heme exacerbates colonic injury induced by anti-cancer therapy oleh Philippa Seika, Monika Janikova, Monika Janikova, Sahana Asokan, Sahana Asokan, Sahana Asokan, Lubica Janovicova, Lubica Janovicova, Eva Csizmadia, Mckenzie O’Connell, Simon C. Robson, Jonathan Glickman, Barbara Wegiel

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Dual EGFR- and TfR-targeted gene transfer for sodium iodide symporter gene therapy of glioblastoma oleh Rebekka Spellerberg, Teoman Benli-Hoppe, Carolin Kitzberger, Mara Hageneier, Nathalie Schwenk, Özgür Öztürk, Katja Steiger, Gabriele Multhoff, Matthias Eiber, Franz Schilling, Wolfgang A. Weber, Roland E. Kälin, Rainer Glass, Peter J. Nelson, Ernst Wagner, Christine Spitzweg

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PDX models recapitulate the genetic and epigenetic landscape of pediatric T‐cell leukemia oleh Paulina Richter‐Pechańska, Joachim B Kunz, Beat Bornhauser, Caroline vonKnebel Doeberitz, Tobias Rausch, Büşra Erarslan‐Uysal, Yassen Assenov, Viktoras Frismantas, Blerim Marovca, Sebastian M Waszak, Martin Zimmermann, Julia Seemann, Margit Happich, Martin Stanulla, Martin Schrappe, Gunnar Cario, Gabriele Escherich, Kseniya Bakharevich, Renate Kirschner‐Schwabe, Cornelia Eckert, Martina U Muckenthaler, Jan O Korbel, Jean‐Pierre Bourquin, Andreas E Kulozik

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Prognostic and Predictive Value of p21-activated Kinase 6 Associated Support Vector Machine Classifier in Gastric Cancer Treated by 5-fluorouracil/Oxaliplatin Chemotherapy oleh Yuming Jiang, Wei Liu, Tuanjie Li, Yanfeng Hu, Sile Chen, Sujuan Xi, Yajia Wen, Lei Huang, Liying Zhao, Cuicui Xiao, Xiaohui Huang, Zhen Han, Hao Liu, Xiaolong Qi, Yang Yang, Jiang Yu, Shirong Cai, Guoxin Li

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Empirical sample-specific approaches to define HPV16 and HPV18 seropositivity in unvaccinated, young, sexually active women oleh Kristy Ng, Samantha Morais, Michel D. Wissing, Ann N. Burchell, Pierre-Paul Tellier, François Coutlée, Tim Waterboer, Mariam El-Zein, Eduardo L. Franco

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Magnetic Resonance Neurography Reveals Smoking-Associated Decrease in Sciatic Nerve Structural Integrity in Type 2 Diabetes oleh Johann M. E. Jende, Christoph Mooshage, Zoltan Kender, Stefan Kopf, Stefan Kopf, Jan B. Groener, Jan B. Groener, Sabine Heiland, Sabine Heiland, Alexander Juerchott, Peter Nawroth, Peter Nawroth, Peter Nawroth, Martin Bendszus, Felix T. Kurz, Felix T. Kurz

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Elective Node Irradiation With Integrated Boost to the Prostate Using Helical IMRT–Clinical Outcome of the Prospective PLATIN-1 Trial oleh Stefan Alexander Koerber, Stefan Alexander Koerber, Stefan Alexander Koerber, Erik Winter, Sonja Katayama, Sonja Katayama, Sonja Katayama, Alla Slynko, Matthias Felix Haefner, Matthias Felix Haefner, Matthias Felix Haefner, Matthias Uhl, Matthias Uhl, Matthias Uhl, Florian Sterzing, Florian Sterzing, Gregor Habl, Gregor Habl, Kai Schubert, Juergen Debus, Juergen Debus, Juergen Debus, Juergen Debus, Juergen Debus, Juergen Debus, Klaus Herfarth, Klaus Herfarth, Klaus Herfarth, Klaus Herfarth

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Active Site Mutations as a Suitable Tool Contributing to Explain a Mechanism of Aristolochic Acid I Nitroreduction by Cytochromes P450 1A1, 1A2 and 1B1 oleh Jan Milichovký, František Bárta, Heinz H. Schmeiser, Volker M. Arlt, Eva Frei, Marie Stiborová, Václav Martínek

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Are Further Cross Section Measurements Necessary for Space Radiation Protection or Ion Therapy Applications? Helium Projectiles oleh John W. Norbury, Giuseppe Battistoni, Judith Besuglow, Judith Besuglow, Luca Bocchini, Daria Boscolo, Alexander Botvina, Martha Clowdsley, Wouter de Wet, Marco Durante, Marco Durante, Martina Giraudo, Thomas Haberer, Lawrence Heilbronn, Felix Horst, Michael Krämer, Chiara La Tessa, Chiara La Tessa, Francesca Luoni, Francesca Luoni, Andrea Mairani, Silvia Muraro, Ryan B. Norman, Vincenzo Patera, Giovanni Santin, Giovanni Santin, Christoph Schuy, Lembit Sihver, Lembit Sihver, Tony C. Slaba, Nikolai Sobolevsky, Albana Topi, Uli Weber, Charles M. Werneth, Cary Zeitlin

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Downregulation of 15-hydroxyprostaglandin dehydrogenase during acquired tamoxifen resistance and association with poor prognosis in ERα-positive breast cancer oleh Milene Volpato, Michele Cummings, Abeer M. Shaaban, Balkees Abderrahman, Mark A. Hull, Philipp Y. Maximov, Bradley M. Broom, Reiner Hoppe, Ping Fan, Hiltrud Brauch, V. Craig Jordan, Valerie Speirs

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Neurocognitive Outcome and Seizure Freedom After Awake Surgery of Gliomas oleh Sarah Christina Reitz, Sarah Christina Reitz, Marion Behrens, Irina Lortz, Nadine Conradi, Maximilian Rauch, Katharina Filipski, Katharina Filipski, Katharina Filipski, Katharina Filipski, Martin Voss, Martin Voss, Martin Voss, Christian Kell, Christian Kell, Marcus Czabanka, Marie-Therese Forster, Marie-Therese Forster

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Oncogene goosecoid is transcriptionally regulated by E2F1 and correlates with disease progression in prostate cancer oleh Yue Ge, Sheng Ma, Qiang Zhou, Zezhong Xiong, Yanan Wang, Le Li, Zheng Chao, Junbiao Zhang, Tengfei Li, Zixi Wu, Yuan Gao, Guanyu Qu, Zirui Xi, Bo Liu, Xi Wu, Zhihua Wang, Yuanyuan Ji

"…We performed a systematic bioinformatics exploration of GSC using datasets from The Cancer Genome Atlas, Genotype-Tissue Expression, Gene Expression Omnibus, German Cancer Research Center, and our in-house cohorts. First, we evaluated the expression of GSC and its association with patient prognosis, and identified GSC-relevant genetic alterations in cancers. …"
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Thyroid dysfunction (TD) induced by PD-1/PD-L1 inhibitors in advanced lung cancer oleh Yanling Wang, Xiaoxuan Yang, Jia Ma, Shenglan Chen, Ping Gong, Ping Dai

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Presence of the GFI1-36N single nucleotide polymorphism enhances the response of MLL-AF9 leukemic cells to CDK4/6 inhibition oleh Jan Vorwerk, Kaiyan Sun, Daria Frank, Felix Neumann, Felix Neumann, Jana Hüve, Paulina Marie Budde, Longlong Liu, Xiaoqing Xie, Pradeep Kumar Patnana, Helal Mohammed Mohammed Ahmed, Bertram Opalka, Georg Lenz, Ashok Kumar Jayavelu, Ashok Kumar Jayavelu, Ashok Kumar Jayavelu, Ashok Kumar Jayavelu, Ashok Kumar Jayavelu, Cyrus Khandanpour, Cyrus Khandanpour

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Impact of inflammatory markers on survival in patients with limited disease small-cell lung cancer undergoing chemoradiotherapy oleh Bernhardt D, Aufderstrasse S, König L, Adeberg S, Bozorgmehr F, Christopoulos P, El Shafie RA, Hörner-Rieber J, Kappes J, Thomas M, Herth F, Steins M, Debus J, Rieken S

"…Denise Bernhardt,1–3,* Sophie Aufderstrasse,1,2,* Laila König,1–3 Sebastian Adeberg,1–4 Farastuk Bozorgmehr,5,6 Petros Christopoulos,5,6 Rami A El Shafie,1,2 Juliane Hörner-Rieber,1–3 Jutta Kappes,6,7 Michael Thomas,5,6 Felix Herth,6,7 Martin Steins,5 Jürgen Debus,1–4 Stefan Rieken1–3 1Department of Radiation Oncology, University Hospital Heidelberg, Heidelberg, Germany; 2Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg, Germany; 3Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany; 4Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany; 5Department of Thoracic Oncology, Thoraxklinik, Heidelberg University, Translational Lung Research Centre Heidelberg (TLRC-H), Heidelberg, Germany; 6German Centre for Lung Research (DZL), Heidelberg, Germany; 7Department of Pneumology, Thoraxklinik, Heidelberg University, Heidelberg, Germany *These authors contributed equally to this work Background: Systemic inflammation appears to play a role in the progression of numerous solid tumors by promoting tumor proliferation. …"
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Whole-brain irradiation with hippocampal sparing and dose escalation on metastases: neurocognitive testing and biological imaging (HIPPORAD) – a phase II prospective randomized mul... oleh Anca-Ligia Grosu, Lars Frings, Iryna Bentsalo, Oliver Oehlke, Franziska Brenner, Angelika Bilger, Jamina Tara Fennell, Thomas Rothe, Sabine Schneider-Fuchs, Erika Graf, Claudia Schmoor, Jürgen Beck, Gerhild Becker, Michael Bock, Karl Egger, Horst Urbach, Claas Lahmann, Ilinca Popp

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DNA Methylation Associates With Clinical Courses of Atypical Meningiomas: A Matched Case–Control Study oleh Matthias Millesi, Matthias Millesi, Alice Senta Ryba, Alice Senta Ryba, Johannes A. Hainfellner, Johannes A. Hainfellner, Thomas Roetzer, Thomas Roetzer, Anna Sophie Berghoff, Anna Sophie Berghoff, Matthias Preusser, Matthias Preusser, Gerwin Heller, Gerwin Heller, Erwin Tomasich, Erwin Tomasich, Felix Sahm, Felix Sahm, Karl Roessler, Karl Roessler, Stefan Wolfsberger, Stefan Wolfsberger

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Targeting CDC7 potentiates ATR-CHK1 signaling inhibition through induction of DNA replication stress in liver cancer oleh Yuchen Guo, Jun Wang, Bente Benedict, Chen Yang, Frank van Gemert, Xuhui Ma, Dongmei Gao, Hui Wang, Shu Zhang, Cor Lieftink, Roderick L. Beijersbergen, Hein te Riele, Xiaohang Qiao, Qiang Gao, Chong Sun, Wenxin Qin, René Bernards, Cun Wang

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