Shaping Nanoparticles with Hydrophilic Compositions and Hydrophobic Properties as Nanocarriers for Antibiotic Delivery oleh Yusilawati Ahmad Nor, Yuting Niu, Surajit Karmakar, Liang Zhou, Chun Xu, Jun Zhang, Hongwei Zhang, Meihua Yu, Donna Mahony, Neena Mitter, Matthew A. Cooper, Chengzhong Yu

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POS-518 DIALYSIS INITIATION IN OLDER PERSONS ACROSS CENTRES AND OVER TIME IN AUSTRALIA AND NEW ZEALAND oleh I. ETHIER, S.B. Campbell, Y. Cho, C.M. Hawley, N.M. Isbel, R. Krishnasamy, M.A. Roberts, D. Semple, M. Sypek, A.K. Viecelli, D.W. Johnson

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RAGE deficiency predisposes mice to virus-induced paucigranulocytic asthma oleh Jaisy Arikkatt, Md Ashik Ullah, Kirsty Renfree Short, Vivan Zhang, Wan Jun Gan, Zhixuan Loh, Rhiannon B Werder, Jennifer Simpson, Peter D Sly, Stuart B Mazzone, Kirsten M Spann, Manuel AR Ferreira, John W Upham, Maria B Sukkar, Simon Phipps

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Recovery rates of combination antibiotic therapy using in vitro microdialysis simulating in vivo conditions oleh Jayesh A. Dhanani, Suzanne L. Parker, Jeffrey Lipman, Steven C. Wallis, Jeremy Cohen, John Fraser, Adrian Barnett, Michelle Chew, Jason A. Roberts

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JAK1 somatic mutation in a myeloproliferative neoplasm oleh Suzanne O. Arulogun, Hock-Lai Choong, Debbie Taylor, Paula Ambrosoli, Graham Magor, Ian M. Irving, Tee-Beng Keng, Andrew C. Perkins

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Optimising Treatment Outcomes for Children and Adults Through Rapid Genome Sequencing of Sepsis Pathogens. A Study Protocol for a Prospective, Multi-Centre Trial (DIRECT) oleh Adam D. Irwin, Adam D. Irwin, Lachlan J. M. Coin, Lachlan J. M. Coin, Patrick N. A. Harris, Menino Osbert Cotta, Michelle J. Bauer, Cameron Buckley, Ross Balch, Peter Kruger, Jason Meyer, Kiran Shekar, Kiran Shekar, Kara Brady, Cheryl Fourie, Natalie Sharp, Luminita Vlad, David Whiley, Scott A. Beatson, Brian M. Forde, David Paterson, Julia Clark, Krispin Hajkowicz, Sainath Raman, Seweryn Bialasiewicz, Jeffrey Lipman, Luregn J. Schlapbach, Luregn J. Schlapbach, Jason A. Roberts

"…We set out to demonstrate the feasibility and diagnostic accuracy of pathogen sequencing direct from clinical samples, and estimate the impact of this approach on time to effective therapy when integrated with personalised software-guided antimicrobial dosing in children and adults on ICU with sepsis.MethodsThe DIRECT study is a pilot prospective, non-randomized multicentre trial of an integrated diagnostic and therapeutic algorithm combining rapid direct pathogen sequencing and software-guided, personalised antibiotic dosing in children and adults with sepsis on ICU.Participants and interventionsDIRECT will collect microbiological and pharmacokinetic samples from approximately 200 children and adults with sepsis admitted to one of four ICUs in Brisbane. In Phase 1, we will evaluate Oxford Nanopore Technologies MinION sequencing direct from blood in 50 blood culture-proven sepsis patients recruited from consecutive patients with suspected sepsis. …"
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Prevalence of Alcohol Consumption in Emergency department presentations (PACE) in Queensland, Australia, using alcohol biomarkers ethanol and phosphatidylethanol: an observational... oleh Tegwen Howell, Jacelle Warren, Cate M Cameron, Kirsten Vallmuur, Victoria McCreanor, Gary Mitchell, Silvia Manzanero, Michael Schuetz, Kim A Vuong, Jacobus P J Ungerer, Brett McWhinney, Clifford Pollard, Anna Zournazi

"…This PACE study will use two biomarkers, blood ethanol and phosphatidylethanol (PEth), to determine the patterns, presence and level of alcohol use in patients presenting to an Australian ED.Methods and analysis This is an observational prevalence study involving the secondary use of routinely collected blood samples from patients presenting to the Royal Brisbane and Women’s Hospital (RBWH) Emergency and Trauma Centre (ETC). …"
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Phenotypic variability within the desminopathies: A case series of three patients oleh Dennis Yeow, Matthew Katz, Robert Henderson, Sandhir Prasad, Russell Denman, Stefan Blum, Mark Davis, Thomas Robertson, Pamela McCombe

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Evaluation of a pilot regional neurotrauma workshop using 3D printed simulation models oleh Nalinda Dissanayaka, Hamish Alexander, Michael Redmond, Patrick Pearce, Andrew Hobbins-King, Kate Lee, Danilo Carluccio, Roozbeh Fakhr, Luigi-Jules Vandi, James I. Novak

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Type I Diabetes Mellitus Increases the Cardiovascular Complications of Influenza Virus Infection oleh Jane E. Sinclair, Conor J. Bloxham, Han Chiu, Keng Yih Chew, Jake Russell, Yusuke Yoshikawa, Helle Bielefeldt-Ohmann, Helle Bielefeldt-Ohmann, Lauren E. Steele, Katina D. Hulme, Nathalie AJ. Verzele, Ellesandra C. Noye, Melanie Wu, Melissa E. Reichelt, Walter G. Thomas, Linda A. Gallo, Meredith A. Redd, Kirsty R. Short

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A phase Ib study to assess the safety of the human papillomavirus DNA vaccine (AMV002) in combination with durvalumab for HPV-associated oropharyngeal squamous cell carcinoma oleh Rahul Ladwa, Rahul Ladwa, Janin Chandra, Wai-Ping Woo, Wai-Ping Woo, Neil Finlayson, Howard Liu, Howard Liu, Margaret McGrath, Adrienne See, Brett G. Hughes, Brett G. Hughes, Caroline L. Cooper, Caroline L. Cooper, Jim E. Jackson, Marcin Dzienis, Yan Xu, Yan Xu, Benedict Panizza, Benedict Panizza, Ian Frazer, Ian Frazer, Sandro V. Porceddu, Sandro V. Porceddu

"…The study was conducted with ethical approval (HREC/2018/QMS/47293) in Brisbane, Australia.FindingsThe most common adverse event (AE) related to vaccine administration was erythema at the injection site. …"
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Laparoscopic resection of a pediatric intestinal leiomyosarcoma oleh Dr David Brough, Dr Greg Miller, Dr Ian Ross, Dr Wayne Nicholls, A/Prof David Cavallucci

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Th17 plasticity and transition toward a pathogenic cytokine signature are regulated by cyclosporine after allogeneic SCT oleh Kate H. Gartlan, Antiopi Varelias, Motoko Koyama, Renee J. Robb, Kate A. Markey, Karshing Chang, Andrew N. Wilkinson, David Smith, Md Ashik Ullah, Rachel D. Kuns, Neil C. Raffelt, Stuart D. Olver, Katie E. Lineburg, Bianca E. Teal, Melody Cheong, Michele W.L. Teng, Mark J. Smyth, Siok-Keen Tey, Kelli P.A. MacDonald, Geoffrey R. Hill

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Calcium channels and iron metabolism: A redox catastrophe in Parkinson's disease and an innovative path to novel therapies? oleh Matthew K. Boag, Linlin Ma, George D. Mellick, Dean L. Pountney, Yunjiang Feng, Ronald J. Quinn, Alan Wee-Chung Liew, Mahendiran Dharmasivam, Mahan Gholam Azad, Rizwana Afroz, Des R. Richardson

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Evaluation of a Genetics Education Program for Health Interpreters: A Pilot Study oleh Miranda E. Vidgen, Lindsay F. Fowles, Lindsay F. Fowles, Satrio Nindyo Istiko, Erin Evans, Erin Evans, Katrina Cutler, Kate Sullivan, Jessica Bean, Louise Healy, Gary Hondow, Aideen M. McInerney-Leo, Aideen M. McInerney-Leo, Gregory Pratt, Gregory Pratt, Deborah Robins, Stephanie Best, Stephanie Best, Keri Finlay, Keri Finlay, Priya Ramarao-Milne, Priya Ramarao-Milne, Nicola Waddell, Nicola Waddell

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Identification and characterization of TM4SF1+ tumor self-seeded cells oleh Haotian Yang, Haolu Wang, Yaowu He, Yang Yang, Erik W. Thompson, Di Xia, Leslie J. Burke, Lu Cao, John D. Hooper, Michael S. Roberts, Darrell H.G. Crawford, Xiaowen Liang

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1091 Tigilanol Tiglate is a small molecule oncolytic that induces immunogenic cell death and promotes immune cell infiltration into human tumors oleh Pei-Yi Yap, Blake Ferguson, Motoko Koyama, Herlina Handoko, Jenny Johns, Praphaporn Stewart, Jason K Cullen, Zara C Bruce, Steven M Ogbourne, Paul W Reddell, Glen M Boyle, Peter G Parsons

Australian general practitioners’ perceptions of the barriers and opportunities for community-based care of patients with viral hepatitis: a mixed methods study oleh Paul Clark, Donata Sackey, Rebecca Farley, Shaouli Shahid, Aidan Woodward, Burglind Liddle, Patricia Valery, Belaynew Taye

"…Methods We conducted a mixed methods study using survey questionnaires (23 GPs) and an open-ended interview guide (10 GPs) at primary care clinics in Brisbane, Queensland, Australia. Quantitative data were analysed using descriptive statistics in Stata 15.1 and qualitative data were analysed using thematic analysis following an inductive approach. …"
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Vocal cord dysfunction after pediatric cardiac surgery: A prospective implementation studyCentral MessagePerspective oleh Louise Kenny, MBBS, MSC, FRCS-CTh, Amy McIntosh, BN, Karen Jardine, BSpPath, Jessica Suna, BN, BSc, GradCer, MHlthSci, Kathryn Versluis, BSc (Health Science), Nicola Slee, MBBS, FRACS, GAICD, Gareth Lloyd, BMBS, BMedSci (hons), FRCS, Robert Justo, MBBS, FRACP, Greg Merlo, BSci, MHEcon, PhD, Mary Wilson, BN, Tristan Reddan, BAppSc, GCHlthSc, GDApps, PhD, AMS, FASA, Jennifer Powell, BA, BSc, MBBS, FRANZCr, Prem Venugopal, FRCS-CTh, Kim Betts, MBiostats, MPH, PhD, Nelson Alphonso, FRCS-CTh

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Assessment and diagnosis of right ventricular failure—retrospection and future directions oleh Sun Kyun Ro, Sun Kyun Ro, Sun Kyun Ro, Kei Sato, Kei Sato, Shinichi Ijuin, Shinichi Ijuin, Shinichi Ijuin, Declan Sela, Declan Sela, Gabriele Fior, Gabriele Fior, Silver Heinsar, Silver Heinsar, Silver Heinsar, Silver Heinsar, Ji Young Kim, Jonathan Chan, Jonathan Chan, Hideaki Nonaka, Aaron C. W. Lin, Aaron C. W. Lin, Gianluigi Li Bassi, Gianluigi Li Bassi, Gianluigi Li Bassi, David G. Platts, David G. Platts, Nchafatso G. Obonyo, Nchafatso G. Obonyo, Nchafatso G. Obonyo, Nchafatso G. Obonyo, Jacky Y. Suen, Jacky Y. Suen, John F. Fraser, John F. Fraser, John F. Fraser

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