Increased burden of ultra-rare structural variants localizing to boundaries of topologically associated domains in schizophrenia
oleh: Matthew Halvorsen, Ruth Huh, Nikolay Oskolkov, Jia Wen, Sergiu Netotea, Paola Giusti-Rodriguez, Robert Karlsson, Julien Bryois, Björn Nystedt, Adam Ameur, Anna K. Kähler, NaEshia Ancalade, Martilias Farrell, James J. Crowley, Yun Li, Patrik K. E. Magnusson, Ulf Gyllensten, Christina M. Hultman, Patrick F. Sullivan, Jin P. Szatkiewicz
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-04-01 |
Deskripsi
Common variants identified by large-scale genomewide association studies cannot account fully account for the heritability of schizophrenia (SCZ). Here, the authors report high-coverage whole-genome sequencing of 1162 SCZ cases and 936 controls and explore the contribution of different types of variants to SCZ.