Polymer-tetrodotoxin conjugates to induce prolonged duration local anesthesia with minimal toxicity
oleh: Chao Zhao, Andong Liu, Claudia M. Santamaria, Andre Shomorony, Tianjiao Ji, Tuo Wei, Akiva Gordon, Hannes Elofsson, Manisha Mehta, Rong Yang, Daniel S. Kohane
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-06-01 |
Deskripsi
There is interest in developing long-lasting local anaesthetics for a range of applications. Here, the authors report on the application of tetrodotoxin conjugated to amphiphilic biodegradable polymer to reduce systemic toxicity, achieve sustained release and investigate application as a local anaesthetic.