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A study was conducted during the cropping seasons of 2009 -10 and 2010 -11 with two plant crops and a ratoon crop at Agricultural Research Station, Perumallapalle, Andhra Pradesh, India, to evaluate the post emergence herbicides for control of creeper weeds in sugarcane. Creeper weed population and dry weight, millable canes and cane yield were significantly influenced by weed management practices. Uncontrolled growth of creeper weeds reduced the yield of sugarcane crop by 30 - 47% in comparison to hand weeding at 30 and 60 days after planting. Among the post emergence herbicides, metribuzine @ 1.25 kg a.i. /ha + 2,4-D sodium salt @ 2 kg a.i./ha realized highest value of cost benefit ratio (2.32) followed by metribuzine @ 1.25 kg a.i./ha + ethoxy sulfuran @ 50 g a.i./ha (2.15). Weed management practices did not influence juice sucrose percent significantly.