Development of the quadrivalent live attenuated influenza vaccine including two influenza B lineages – Victoria and Yamagata
oleh: Yu. A. Desheva, T. A. Smolonogina, E. M. Doroshenko, L. G. Rudenko
| Format: | Article |
|---|---|
| Diterbitkan: | Central Research Institute for Epidemiology 2016-02-01 |
Deskripsi
This work is devoted to the research of the live attenuated influenza vaccine (LAIV) comprising two reassortant B/USSR/60/69-based vaccine influenza viruses Victoria and Yamagata. the intranasal immunization of the CBA mice with both victoria and yamagata strains induced 100% lung protection against the subsequent infection with the wild-type influenza B viruses of any antigen lineage. the quadrivalent LAIV (qLAIV) comprising both reassortant influenza B viruses Victoria and Yamagata were safe and areactogenic in adult volunteers. Following qLAIV administration the immune response was achieved to both Victoria and Yamagata lineages.