Structural basis of substrate recognition and translocation by human very long-chain fatty acid transporter ABCD1
oleh: Zhi-Peng Chen, Da Xu, Liang Wang, Yao-Xu Mao, Yang Li, Meng-Ting Cheng, Cong-Zhao Zhou, Wen-Tao Hou, Yuxing Chen
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-06-01 |
Deskripsi
Human ABC transporter ABCD1 transports very long-chain fatty acids from cytosol to peroxisome for βoxidation, dysfunction of which causes the X-ALD. Here, the authors report three structures of ABCD1: the ligand-free, C22:0-CoA- and ATP-bound forms.