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The increase in the insecticide resistance of pests, such as <i>Mythimna separata</i>, <i>Aphis craccivora Koch</i>, and <i>Tetranychus cinnabarinus</i>, necessitates the development of new heterocyclic compounds with high insecticidal activity. A series of novel 2-phenylpyridine derivatives containing <i>N</i>-phenylbenzamide moieties were designed and synthesised with Suzuki–Miyaura cross-coupling, nucleophilic substitution, and amidation reactions. The reaction conditions in each step are mild, and the product is easy to separate (yield is about 85%). The structures of the compounds were characterised using ¹H and ¹³C NMR spectroscopy and HRMS. Moreover, the insecticidal activity of the compounds was analysed using the leaf dipping method. The compounds <b>5a</b>, <b>5d</b>, <b>5g</b>, <b>5h</b>, and <b>5k</b> at 500 mg/L exhibited 100% inhibition against <i>Mythimna separata</i>. Therefore, the 2-phenylpyridine moieties have the potential to lead to the discovery of novel and effective insecticides.