Relapse of Tropheryma whipplei endocarditis treated by trimethoprim/sulfamethoxazole, cured by hydroxychloroquine plus doxycycline
oleh: Stephane Emonet, Timothee Wuillemin, Stephan Harbarth, Nasstasja Wassilew, Mustafa Cikirikcioglu, Jacques Schrenzel, Jean-Christophe Lagier, Didier Raoult, Christian van Delden
| Format: | Article |
|---|---|
| Diterbitkan: | Elsevier 2015-01-01 |
Deskripsi
The best treatment for Tropheryma whipplei infections is controversial. We report a patient who suffered from T. whipplei aortic native valve endocarditis that relapsed despite surgery and four weeks of intravenous ceftriaxone followed by several months of oral trimethoprim/sulfamethoxazole. Cure was achieved after replacement of the prosthesis with a homograft and 18 months of oral doxycycline-hydroxychloroquine. We discuss the need for a change in treatment guidelines for T. whipplei infections.