An inner activation gate controls TMEM16F phospholipid scrambling
oleh: Trieu Le, Zhiguang Jia, Son C. Le, Yang Zhang, Jianhan Chen, Huanghe Yang
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-04-01 |
Deskripsi
TMEM16F is an enigmatic Ca2 + -activated phospholipid scramblase (CaPLSase) that passively transports phospholipids. Here authors identify an inner activation gate and its disruption profoundly alters TMEM16F phospholipid permeation.