Find in Library

The <i>Panax notoginseng</i>@Ag core/shell electrospun fiber membrane was prepared by coaxial electrospinning combined with the UV reduction method (254 nm). The prepared <i>Panax notoginseng</i>@Ag core/shell nanofiber membrane has a three-dimensional structure, and its swelling ratio could reach as high as 199.87%. Traditional Chinese medicine <i>Panax notoginseng</i> can reduce inflammation, and the silver nanoparticles have antibacterial effects, which synergistically promote rapid wound healing. The developed <i>Panax notoginseng</i>@Ag core/shell nanofiber membrane can effectively inhibit the growth of the Gram-negative bacteria <i>Escherichia coli</i> and the Gram-positive bacteria <i>Staphylococcus aureus</i>. The wound healing experiments in Sprague Dawley mice showed that the wound residual area rate of the <i>Panax notoginseng</i>@Ag core/shell electrospun nanofiber membrane group was only 1.52% on day 9, and the wound of this group basically healed on day 12, while the wound residual area rate of the gauze treatment group (control group) was 16.3% and 10.80% on day 9 and day 12, respectively. The wound of the <i>Panax notoginseng</i>@Ag core/shell electrospun nanofiber membrane group healed faster, which contributed to the application of the nanofiber as Chinese medicine rapid wound healing dressings.