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The aim of this paper is to consider, from the epidemiological-clinic aspect,frequency and dispersion of the AIM in the marl and urban population of NišMunicipality. Tn the period from 1974 to 1994 at the Cardiological Clinic of Ni.šClinic center there were 4.344 patients treated from the ATM, on average 167annually with a year incidence rate of 11 1,37 patients per 100.000 inhabitants above30. The incidence rate of the AIM in the overall Municipality population in the last 3decades shows a permanent growth with the culmination in 1998 when it amounted to21 8,7/100.000 which is two times larger than the average annual rate for the periodfrom 1974 to 1983 (111,05/100.000). For the period from 1984 to 1994 the rate was 15K,24 while for the period from 1995 to 1999 il amounted to 186,6/100.000inhabitants above 30 years of age. The rate shows an increase in both sexcs and il isalso higherv vithmales.Thereliofortheperiod from 1974lo 19X3 was 1:3,for I9K4IO1994 it was 1:2,9. while for the period 1995-1999 it decreased lo 1:2.2 which speaksabout greater occurrence among women in the last decade. Thc. linear trend of l'heincidence rate in men (yt=232,9+I3,46x) and in women (yt=95+l 1,65x) shows thalthe talc tends lo increase and Ihal the AIM will be a first-rate clinic and social-medicalproblem of the future generations. The incidence rales are in direcl positivecorrelation with age groups of the population in both sexcs and botli the populations.The largest rates in the urban population are in the agc group of 70 to 79 years of age(1161,6 male and 915,1 women in the period from 1995 to 1999). Among the sexesthe greatest differences are in the age groups from 40 lo 49 and 50 to 59 at the ratio of1:4 for men. The average men age for the period from 1995 to 1999 was 61,2+10,97while for women it was 65,7+10,7; the difference is significunt for the level p<0,001.The given relations mostly characterize the urban population. With the ruralpopulation, the rates are considerably lower and do not show anv tendency loincrease. The average annual rate for the period from 1995 lo 1999 was 22/100.000inhabitants above 30 years of age and it was 11,5 lower than the urban population rate(254,0/100.000). All the patents were older than 50 years. The average men age was66,9 while the women one was 69,3; they were considerably older llian the urbanpopulation.