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This paper presents medical information systems (MIS) as a powerful source for education and research in modern medicine. Paper gives an overview of functionalities of MIS system, emphasizing reporting and data analysis techniques as basic knowledge extracting methods. These two are considered as the most important functionalities for successful use of data from medical information systems in medical education and research processes. Also, general remarks on other possible usage of MIS in education and research in medicine are presented here and illustrated with examples from MEDIS. NET information system, developed in Laboratory for Medical Informatics of Faculty of Electronic Engineering in Niš.