Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer
oleh: Steffen Grampp, James L. Platt, Victoria Lauer, Rafik Salama, Franziska Kranz, Viviana K. Neumann, Sven Wach, Christine Stöhr, Arndt Hartmann, Kai-Uwe Eckardt, Peter J. Ratcliffe, David R. Mole, Johannes Schödel
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-10-01 |
Deskripsi
Genome-wide association studies have identified multiple loci associated with the risk of developing renal cancer. Here, the authors show that one of these loci generates open chromatin, which enhances the binding of HIF and HIF-mediated transactivation ofMYC.