The germline factor DDX4 contributes to the chemoresistance of small cell lung cancer cells
oleh: Christopher Noyes, Shunsuke Kitajima, Fengkai Li, Yusuke Suita, Saradha Miriyala, Shakson Isaac, Nagib Ahsan, Erik Knelson, Amir Vajdi, Tetsuo Tani, Tran C. Thai, Derek Xu, Junko Murai, Nikos Tapinos, Chiaki Takahashi, David A. Barbie, Mamiko Yajima
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2023-01-01 |
Deskripsi
DDX4, a conserved germline factor and RNA helicase, increases small cell lung cancer cell survival by regulating DNA damage and immune response pathways and contributes to cisplatin-mediated drug resistance.