Inflammation and immune activation are associated with risk of Mycobacterium tuberculosis infection in BCG-vaccinated infants
oleh: Iman Satti, Rachel E. Wittenberg, Shuailin Li, Stephanie A. Harris, Rachel Tanner, Deniz Cizmeci, Ashley Jacobs, Nicola Williams, Humphrey Mulenga, Helen A. Fletcher, Thomas J. Scriba, Michele Tameris, Mark Hatherill, Helen McShane
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-11-01 |
Deskripsi
The identification of immune correlates of protection in humans would inform on the design and development of tuberculosis vaccine candidates. In this work, authors examine samples collected from South African infants, to determine whether the correlates of risk of tuberculosis disease, previously identified in this population, are also correlates of risk of M. tuberculosis infection.