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Mesophilic aeromonads are being increasingly reported pathogen of humans and lower vertebrates. Water and foods are considered to be the chief source of Aeromonas spp. At present there are several techniques available for the detection of Aeromonas spp. from water and foods. However, there is still need to develop immunodiagnostics for rapid detection of Aeromonas spp. irrespective of their species or serotype. To meet out this requirement present study was undertaken to identify the common protein moiety in their OMPs by SDS-PAGE so, that immunoassays can be developed for efficient and rapid detection of Aeromonas spp. from foods. [Vet. World 2012; 5(3.000): 173-177]