Racial differences in α4β7 expression on CD4+ T cells of HIV-negative men and women who inject drugs.
oleh: Alyssa R Martin, Aida Sivro, Zoe R Packman, Eshan U Patel, Livia R Goes, Lyle R McKinnon, Jacquie Astemborski, Gregory D Kirk, Shruti H Mehta, Claudia Cicala, James Arthos, Andrew D Redd, Thomas C Quinn
| Format: | Article |
|---|---|
| Diterbitkan: | Public Library of Science (PLoS) 2020-01-01 |
Deskripsi
<h4>Introduction</h4>We performed a cross-sectional study of HIV-uninfected men and women who inject drugs from the ALIVE cohort to examine if black men and women who inject drugs have higher levels of CD4+ T cells expressing the integrin heterodimer α4β7 compared to white men and women.<h4>Materials and methods</h4>Flow cytometry was used to examine expression of α4β7 and other markers associated with different functional CD4+ T cell subsets in both men and women who inject drugs.<h4>Results</h4>Higher levels of α4β7, CCR5, and CCR6 were observed on CD4+ T cells from black participants compared with white participants. In a multivariable model, α4β7 expression differed by race, but not sex, age, or other factors.<h4>Discussion</h4>Black men and women express higher percentages of α4β7 expressing CD4+ T cells, which may play a role in HIV disease.