Retrospective analysis of somatic mutations and clonal hematopoiesis in astronauts
oleh: Agnieszka Brojakowska, Anupreet Kour, Mark Charles Thel, Eunbee Park, Malik Bisserier, Venkata Naga Srikanth Garikipati, Lahouaria Hadri, Paul J. Mills, Kenneth Walsh, David A. Goukassian
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-08-01 |
Deskripsi
Deep targeted DNA sequencing of peripheral blood mononuclear cells isolated from blood samples from 14 astronauts who flew Shuttle missions between 1998–2001 identifies 34 non-silent mutations, predominantly in TP53 and DNMT3A.