Engineering of high-precision base editors for site-specific single nucleotide replacement
oleh: Junjie Tan, Fei Zhang, Daniel Karcher, Ralph Bock
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-01-01 |
Deskripsi
Base editors can target multiple bases within a window around the target site, reducing their specificity. Here the authors engineer the connection between the deaminase and Cas domain to narrow the window of activity.