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<span><strong>Background: </strong><span>Health literacy (HL) has important implications for health outcomes in heart failure<br /><span>(HF) patients. Studying health literacy requires culturally appropriate and valid instruments. The aim<br /><span>of the study was validation of the Persian version of the heart failure-specific health literacy scale<br /><span>(HF-Specific HL Scale).<br /><span><strong>Methods: </strong><span>One hundred patients with heart failure were selected in Qom, Iran in 2017. The ‘forwardbackward’ procedure was applied to translate the questionnaire from English into Persian. Content<br /><span>validity, face validity, construct validity have been employed to validate the prepared scale. Cronbach’s<br /><span>alpha coefficients and the test-retest were used to assess the scale reliability. Data were analyzed using<br /><span>SPSS, version 16, and Smart PLS 3.0 software.<br /><span><strong>Results: </strong><span>Confirmatory factor analysis completely supported the three-factor model of the HL scales.<br /><span>Convergent validity was satisfied in that all factor loadings and the average variance extracted<br /><span>exceeded 0.5. The divergent validity was verified using Fornel and Larcker method. R-square and<br /><span>path coefficient were higher than 0.43 and 0.65 respectively, indicating the good structural model.<br /><span>Composite reliability and Cronbach’s <span>α <span>coefficient for all of the constructs were over the recommended<br /><span>threshold of 0.70, ensuring adequate internal consistency of the scale. The test-retest reliability ranged<br /><span>from 0.78-0.90, which indicated a good level of stability.<br /><span><strong>Conclusion: </strong><span>The findings indicated that the Persian HF-specific HL scale is reliable and valid for<br /><span>measuring health literacy among heart failure patients. Further research is required to measure the<br /><span>sensitivity and specificity of the scale.</span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span><br /></span></span></span></span></span></span></span>