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Accurate detection and automatic processing of earthquake-damaged regions is essential for effective rescue and post-disaster reconstruction. In this study, we proposed a Combined Super-pixel Segmentation and AlexNet Detection approach (CSSAD) for automatically extracting damaged regions from post-earthquake high-resolution images. Simple Linear Iterative Clustering (SLIC) algorithm was used to segment the high resolution images to obtain more homogeneous geo-objects. Multiscale samples database, which took the different scale effect of damaged regions into account, was constructed based on the geometric centre of each super-pixel. AlexNet, which achieved the automatic extraction of high-level features and accurate identification of target geo-objects, was used to detect the damaged regions. To enhance the localization accuracy, the output of AlexNet was further refined using super-pixel segmentations and masked out of shadow and vegetation. Compared with traditional method, the proposed approach effectively reduces the false and missed detection ratio at least 10 percent.