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CD44 upregulation in E-cadherin-negative esophageal cancers results in cell invasion.
oleh: Grégoire F Le Bras, Gillian L Allison, Nicole F Richards, Shazia S Ansari, M Kay Washington, Claudia D Andl
Format: | Article |
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Diterbitkan: | Public Library of Science (PLoS) 2011-01-01 |
Deskripsi
E-cadherin is frequently lost during epithelial-mesenchymal transition and the progression of epithelial tumorigenesis. We found a marker of epithelial-mesenchymal transition, CD44, upregulated in response to functional loss of E-cadherin in esophageal cell lines and cancer. Loss of E-cadherin expression correlates with increased expression of CD44 standard isoform. Using an organotypic reconstruct model, we show increased CD44 expression in areas of cell invasion is associated with MMP-9 at the leading edge. Moreover, Activin A increases cell invasion through CD44 upregulation after E-cadherin loss. Taken together, our results provide functional evidence of CD44 upregulation in esophageal cancer invasion.