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Background: The control of parenchymal hemorrhage, especially in liver parenchyma, despite surgical science progresses, is still one of the challenges surgeons face saving the patients’ lives; and there is a research challenge between the researchers in this field to introduce a more effective method. This study aimed to determine the hemostatic effect of zinc chloride on controlling the bleeding from liver parenchymal tissue. Methods: In this animal model study, 60 male Wistar rats were used. An incision with length of 2 and depth of 0.5 cm was made on each mouse’s liver and the hemostasis time was measured using zinc chloride different concentrations (5%, 10%, 15%, 25%, and 50%) and the control method (i.e. control of bleeding via suturing). Findings: In all the groups, complete hemostasis occurred; the hemostasis times of zinc chloride concentration groups were significantly less than that of the control group (P < 0.001). At concentrations of 5%, 10% and 15% of zinc chloride and suture group, pathological grade one was seen. In addition, in the 25% and 50% zinc chloride groups, pathological grade two was the most common grade (70% and 80%, respectively). Conclusion: Zinc chloride is an effective hemostatic agent in controlling liver parenchymal tissue hemorrhage in an animal model; it can control the liver bleeding, also at the lowest concentration (5%).