Analysis of diverse double-strand break synapsis with Polλ reveals basis for unique substrate specificity in nonhomologous end-joining
oleh: Andrea M. Kaminski, Kishore K. Chiruvella, Dale A. Ramsden, Katarzyna Bebenek, Thomas A. Kunkel, Lars C. Pedersen
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-07-01 |
Deskripsi
Using X-ray crystallography and nonhomologous end-joining assays, this study reveals structural features within Polλ that provide it with the ability to bridge and stabilize tenuous DNA double-strand break ends, allowing for religation.