A DNA packaging motor inchworms along one strand allowing it to adapt to alternative double-helical structures
oleh: Juan P. Castillo, Alexander B. Tong, Sara Tafoya, Paul J. Jardine, Carlos Bustamante
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-06-01 |
Deskripsi
Ring ATPase translocases that operate on disordered substrates adopt lockwasher architectures and use a hand-over-hand mechanism. By challenging the dsDNA packaging motor of bacteriophage ϕ29 with hybrid and dsRNA, the authors propose that the motor cycles between planar and lock-washer structures.