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AIM: To observe the treatment efficacy of eyelid herpeszoster with external use ganciclovir ophthalmic gel. <p>METHODS:A total of 77 patients were randomly divided into treatment group and control group. In the treatment group, ganciclovir ophthalmic gel was topical coated on the basis of antiviral drugs, while the control group was coated with conventional acyclovir ointment and antiviral treatment. <p>RESULTS: The cure rate was 95% in the treatment group, and the control group was 83% after 10d treatment. The difference was significant. <p>CONCLUSION: The efficacy of ganciclovir ophthalmic gel treated eyelid herpes zoster is obvious.