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Development of risk factors of the common carotrid and femoral arteries stiffness was assessed in patients with pre-dialysis chronic renal disease of non-diabetic etiology. It was shown that vascular remodeling was affected by the conventional risk factors such as patients'' age, hypertension, and smoking. A trend to existence of dependence between renal risk factors (hypercreatinemia and disturbances of phosphor-calcium metabolism) and rigidity of the common carotid arteries is also noted.