Antibiotic collateral sensitivity is contingent on the repeatability of evolution
oleh: Daniel Nichol, Joseph Rutter, Christopher Bryant, Andrea M. Hujer, Sai Lek, Mark D. Adams, Peter Jeavons, Alexander R. A. Anderson, Robert A. Bonomo, Jacob G. Scott
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-01-01 |
Deskripsi
The evolution of resistance to an antibiotic can render bacteria more susceptible, or more resistant, to a second antibiotic. Here, Nichol et al. provide evidence that the final outcome can be fairly stochastic and depends on the shape of the evolutionary fitness landscape.