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The aim of this study was establish if the fructooligosaccharides (FOS) and inulin alone or together attenuate age related bone loss in skeletally mature female rats. Forty 10-month old female rats were randomly assigned to four diet groups for 2 months: control, FOS, inulin and FOS + inulin. Bone mineral density (BMD) using dualenergy X-ray absorptiometry (DXA), femur quality using morphometry and biomechanic properties, biochemical assays by the determination of serum parathyroid hormone (PTH), alkaline phosphatase activity (ALP), degradation products of C-terminal peptides of type I collagen (CTX-I), osteocalcin (OC), osteoprotegerin (OPG) and nuclear factor κappa B ligand (RANk-L). The FOS increased hip axis BMD (0.255 ± 0.005 g/cm2 ) and femur neck width (2.19 ± 0.01 mm) and reduced PTH (4.0 x 10-3 ± 0.0006 µg/L), FOS + inulin increased the femur proportional limit (87.2 ± 1.0 N) and reduced PTH (2.5 x 10-3 ± 0.0006 µg/L) and ALP (23.2 ± 5.1 U/L), all the prebiotics reduced OPG (FOS = 1.1 ± 0.3, inulin = 1.1 ± 0.3, FOS + inulin = 1.4 ± 0.4 µg/L) and RANk-L (FOS = 1.65 x 10-2 ± 0.003, inulin = 1.78 x 10-2 ± 0.003, FOS + inulin = 2.83 x 10-2 ± 0.006 µg/L ), no prebiotics changed OC and CTX-I. The results suggested that the consumption of FOS or FOS + inulin may reduce the bone turnover, however, further studies about prebiotics and their synergistic effect on age related bone loss are required.