Four New Limonoids from the Barks of Toona ciliata
oleh: Pan-Pan Zhang, Yun-Ge Bu, Shang Xue, Zhi-Rong Cui, Peng-Fei Tang, Jun Luo, Ling-Yi Kong
| Format: | Article |
|---|---|
| Diterbitkan: | SpringerOpen 2020-10-01 |
Deskripsi
Abstract Four new limonoids, toonayunnanaes F − I (1 − 4), and six known compounds (5 − 10) were isolated from the barks of Toona ciliata. Their structures were elucidated by thoroughly analyzing of NMR and HRMS data, and single-crystal X-ray diffraction of 1. The oxetane ring moiety in 1 was rare in limonoids and other natural products. Compound 1 showed nitric oxide (NO) inhibitory effect with an IC50 38.45 ± 0.41 µM in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages. Graphic Abstract