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AbstractRapid determination of the most-affected areas after an earthquake can help with emergency relief efforts, which is also an essential part of postearthquake relief work. Mobile signaling data contains rich user information, which helps determine the most-affected areas. This study investigated the 2022 Mw 6.6 Luding earthquake in Sichuan, China; the relationship between mobile signaling data and the seismically most-affected area was explored using comparative, regression, and spatial interpolation analysis. The results revealed that mobile signaling data changed abnormally following the earthquake and differed across high- and low-intensity zones. There was a significant correlation between mobile signaling data and intensity. Additionally, the most-affected areas estimated using mobile signaling data were comparable to the actual seismic damage. Therefore, mobile signaling data can provide a reference for determining the most-affected areas and assist in emergency relief efforts after an earthquake.