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Introduction: Colonic perforations are known complications of percutaneous nephrolithotomy (PCNL). However, to the best of our knowledge, small bowel perforation has rarely been reported.. Observation: We report the case of a 7-year-old girl who presented with a duodenal perforation in the early postoperative period after undergoing PCNL for a calculus sized 2.5 cm in the right renal pelvis. She was successfully managed conservatively. The diagnostic workup and management are discussed.