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Following the outbreak of novel coronavirus disease 2019 (COVID-19), there have been debates among scientific communities, officials, and the public about the role of the mask in controlling and preventing this disease. Nonetheless, there are some ambiguities regarding various aspects of the mask which are still important to be addressed, including the type of the mask to be used, the situation in which the mask should be used, the correct way to use the mask, and the effectiveness of the mask in preventing the disease. Accordingly, addressing these ambiguities could change policy trends and public beliefs about the use of mask and help control the disease. To this end, this study discusses the role of the mask in preventing and controlling the COVID-19 pandemic.