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Synthesis and Characterization of Bioactive Magnetic Nanoparticles from the Perspective of Hyperthermia Applications
oleh: Elena-Alina Moacă, Vlad Socoliuc, Dana Stoian, Claudia Watz, Daniela Flondor, Cornelia Păcurariu, Robert Ianoș, Cristiana Iulia Rus, Lucian Barbu-Tudoran, Alexandra Semenescu, Cristian Sarău, Adelina Chevereșan, Cristina Adriana Dehelean
Format: | Article |
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Diterbitkan: | MDPI AG 2022-11-01 |
Deskripsi
Magnetic iron oxide nanoparticles were obtained for the first time via the green chemistry approach, starting from two aqueous extracts of wormwood (<i>Artemisia absinthium</i> L.), both leaf and stems. In order to obtain magnetic nanoparticles suitable for medical purposes, more precisely with hyperthermia inducing features, a synthesis reaction was conducted, both at room temperature (25 °C) and at 80 °C, and with two formulations of the precipitation agent. Both the quality and stability of the synthesized magnetic iron oxide nanoparticles were physiochemically characterized: phase composition (X-ray powder diffraction (XRD)), thermal behavior (thermogravimetry (TG) and differential scanning calorimetry (DSC)), electron microscopy (scanning (SEM) and transmission (TEM)), and magnetic properties (DC and HF-AC). The magnetic investigation of the as-obtained magnetic iron oxide nanoparticles revealed that the synthesis at 80 °C using a mixture of NaOH and NH<sub>3</sub>(aq) increases their diameter and implicitly enhances their specific absorption rate (SAR), a mandatory parameter for practical applications in hyperthermia.