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Human lifespan and life expectancy have increased worldwide, but the number of years that we spend free of chronic or debilitating disorders, known as healthspan, has not shifted along with increased lifespan. This unfavourable trend presents a tremendous global social-economical problem. We propose a model of promoting optimal human health with proactive, holistic interventions across the lifespan, which require multi-disciplinary, innovative approaches to research and care. We contend that this is the only hope that we have to face the challenges of population growth and aging, as well as the upward trend in non-communicable disease prevalence. Keywords: Healthspan, Aging, Chronic disease, Holistic, Multi-disciplinary