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Introduction: N-3 and N-6 polyunsaturated fatty acids has many involvements in activities within or entering in regulating various physiological processes and in certain pathologies. Among systemic physiological effects in which they are involved we mention the central nervous system development and recall of the retina, regulating plasma lipid levels, cardiovascular and immune system functions, regulating the activity of insulin. Material and methods: The experiment there were used 60 male Wistar rats , weight 180 ± 20 grams, procured from the animal farm of the Department of Pathophysiology, University of Medicine and Pharmacy “Gr.T. Popa”, Iaşi. Male Wistar rats were divided into two study groups: normal control animals (M) and test animals. Test group was further divided into three groups - each group being composed of 15 animals. Administration of the substances was made for 36 weeks (nine months), after which the animals were evaluated and subsequently sacrificed. Results: Following statistical analysis, we determined the following: • Averages of AGP n3 were significantly higher in groups 2 (p <0.001) and 3 (p <0.001) compared with group 4  • Averages ratio n6: n3 in nerve cell membrane were significantly lower in groups 2 (p <0.001) and 3 (p <0.001) compared with group 4  Discussions: Our experiment demonstrates that increased amounts of polyunsaturated fatty acids in the membranes of nerve cells which can justify the positive evolution of animals in assessing the performance of concomitant behavioral tests. Conclusions: This study brings new light on the importance of the existence of a balance between PUFA intake and daily diet.