A tumour-selective cascade activatable self-detained system for drug delivery and cancer imaging
oleh: Hong-Wei An, Li-Li Li, Yi Wang, Ziqi Wang, Dayong Hou, Yao-Xin Lin, Sheng-Lin Qiao, Man-Di Wang, Chao Yang, Yong Cong, Yang Ma, Xiao-Xiao Zhao, Qian Cai, Wen-Ting Chen, Chu-Qi Lu, Wanhai Xu, Hao Wang, Yuliang Zhao
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-10-01 |
Deskripsi
The activation of drugs within cellular systems may provide targeted therapies for cancer. Here, the authors make a drug delivery system that is activated within the cell and exploits XIAP expression to cleave a linker region, resulting in the self-assembly of the system and drug release within cancer cells.