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A novel Schiff base compound, C20H27NO2, was obtained by a condensation of rimantadine and 2-hydroxy-4-methoxybenzaldehyde. An intramolecular O—H...N hydrogen bond supports the phenol–imine tautomeric form. The adamantane and iminomethyl-4-methoxyphenol units are arranged in a folded conformation [C—N—C—C torsion angle = 110.9 (3)°]. In the crystal, highly hydrophobic adamantane moieties are inserted between the iminomethyl-4-methoxyphenol units in a sandwich-like arrangement along the c axis.